PMID- 14715396
OWN - NLM
STAT- MEDLINE
DCOM- 20040322
LR  - 20190818
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 107
IP  - 1-2
DP  - 2004 Jan
TI  - Effects of 1-Hz repetitive transcranial magnetic stimulation on acute pain 
      induced by capsaicin.
PG  - 107-15
AB  - The aim of this study is to investigate the efficacy of 1-Hz repetitive 
      transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) on 
      acute pain induced by intradermal capsaicin injection and to elucidate its 
      mechanisms by single-photon emission computed tomography (SPECT). We compared 
      time courses of a subjective scale of pain induced by intradermal capsaicin 
      injection in seven normal subjects under three different conditions: rTMS over 
      M1, sham stimulation, and control condition (natural course of acute pain without 
      any stimulation). In ten normal subjects, using SPECT, we also studied 
      differences in regional cerebral blood flow (rCBF) after capsaicin injection 
      between two conditions: rTMS over M1 and the control condition. rTMS over M1 
      induced earlier recovery from acute pain compared with the sham or control 
      conditions. Under rTMS over the right M1 condition compared with the control 
      condition, the SPECT study demonstrated a significant relative rCBF decrease in 
      the right medial prefrontal cortex (MPFC) corresponding to Brodmann area (BA) 9, 
      and a significant increase in the caudal part of the right anterior cingulate 
      cortex (ACC) corresponding to BA24 and the left premotor area (BA6). A 
      region-of-interest analysis showed significant correlation between pain reduction 
      and rCBF changes in both BA9 and BA24. We conclude that rTMS over M1 should have 
      beneficial effects on acute pain, and its effects must be caused by functional 
      changes of MPFC and caudal ACC.
FAU - Tamura, Yohei
AU  - Tamura Y
AD  - Department of Neurology, Jikei University School of Medicine, 3-25-8 
      Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. y.tamura@jikei.ac.jp
FAU - Okabe, Shingo
AU  - Okabe S
FAU - Ohnishi, Takashi
AU  - Ohnishi T
FAU - N Saito, Daisuke
AU  - N Saito D
FAU - Arai, Noritoshi
AU  - Arai N
FAU - Mochio, Soichiro
AU  - Mochio S
FAU - Inoue, Kiyoharu
AU  - Inoue K
FAU - Ugawa, Yoshikazu
AU  - Ugawa Y
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Radiopharmaceuticals)
RN  - H25WJA31XE (technetium Tc 99m bicisate)
RN  - K848JZ4886 (Cysteine)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain Mapping
MH  - *Capsaicin
MH  - Cerebrovascular Circulation
MH  - Cysteine/*analogs & derivatives/pharmacokinetics
MH  - Electric Stimulation/*methods
MH  - Electric Stimulation Therapy
MH  - Functional Laterality
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiopathology
MH  - Organotechnetium Compounds/pharmacokinetics
MH  - Pain/chemically induced
MH  - *Pain Management
MH  - Pain Measurement
MH  - Radiopharmaceuticals/pharmacokinetics
MH  - Regional Blood Flow/drug effects/physiology
MH  - Statistics as Topic
MH  - Time Factors
MH  - Tomography, Emission-Computed, Single-Photon/methods
MH  - *Transcranial Magnetic Stimulation
EDAT- 2004/01/13 05:00
MHDA- 2004/03/23 05:00
CRDT- 2004/01/13 05:00
PHST- 2004/01/13 05:00 [pubmed]
PHST- 2004/03/23 05:00 [medline]
PHST- 2004/01/13 05:00 [entrez]
AID - S0304395903004111 [pii]
AID - 10.1016/j.pain.2003.10.011 [doi]
PST - ppublish
SO  - Pain. 2004 Jan;107(1-2):107-15. doi: 10.1016/j.pain.2003.10.011.