PMID- 14717043
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20061115
IS  - 0037-9085 (Print)
IS  - 0037-9085 (Linking)
VI  - 96
IP  - 4
DP  - 2003 Nov
TI  - [Epidemiology of malaria in a village of Sudanese savannah in Mali (Bancoumana). 
      Anti-TRAP and anti-CS humoral immunity response].
PG  - 287-90
AB  - Vaccine development research is an important component of malaria control 
      strategies. Thrombospondin related anonymous protein (TRAP) and the 
      circumsporozoite (CS) protein are two antigens of sporozoite surface. Immune 
      response to these two antigens may contribute to the development of 
      anti-sporozoite vaccine. Recent studies suggest that antibodies anti-TRAP may 
      partially block sporozoites penetration in hepatocyte, and thereby reducing 
      malaria morbidity. We carried out a study to assess the seroprevalence of 
      anti-TRAP and anti-CS antibodies and to identify a possible role of these 
      antibodies on malaria morbidity in children 1-9 years old living in a rural 
      hyperendemic village. We performed 5 cross sectional surveys and a longitudinal 
      follow up in 1993 and 1994. During each cross sectional study, children were 
      examined for fever and splenomegaly; all febrile children received thick film 
      examination, and serologic analysis was performed in one third of these, randomly 
      selected. The results show that the seroprevalence of anti-TRAP and anti-CS 
      varied with age and season (p < 0.05). Association between the prevalence of 
      anti-TRAP and splenomegaly was observed during two cross sectional surveys (June 
      and October 1993). The presence of anti-TRAP antibody was associated with 
      Plasmodium falciparum infection at the beginning of the transmission season (June 
      1993 and July 1994). A negative association between the level of anti-TRAP title 
      and parasitemia was observed (March and October 1994). These findings suggest no 
      clear evidence of the protective role of anti-TRAP antibodies in uncomplicated 
      malaria, possibly due to the limited persistence of these antibodies under 
      natural situations.
FAU - Dolo, A
AU  - Dolo A
AD  - Departement d'epidemiologie des affections parasitaires, Faculte de medecine, de 
      pharmacie et d'odonto-stomalogie, BP 1805, Bamako, Mali. adolo@mrtcbko.org
FAU - Poudiougo, B
AU  - Poudiougo B
FAU - Modiano, D
AU  - Modiano D
FAU - Camara, F
AU  - Camara F
FAU - Kouriba, B
AU  - Kouriba B
FAU - Diallo, M
AU  - Diallo M
FAU - Bosman, A
AU  - Bosman A
FAU - Crisanti, A
AU  - Crisanti A
FAU - Robson, K
AU  - Robson K
FAU - Doumbo, O
AU  - Doumbo O
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Epidemiologie du paludisme dans un village de savane soudanienne du Mali 
      (Bancoumana). 1. Reponse immunitaire humorale anti-TRAP et anti-CS.
PL  - France
TA  - Bull Soc Pathol Exot
JT  - Bulletin de la Societe de pathologie exotique (1990)
JID - 9212564
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Protozoan Proteins)
RN  - 0 (circumsporozoite protein, Protozoan)
RN  - 120300-02-9 (thrombospondin-related adhesive protein, protozoan)
SB  - IM
MH  - Antibodies, Protozoan/*blood
MH  - Antibody Formation
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Endemic Diseases
MH  - Fever
MH  - Humans
MH  - Infant
MH  - Longitudinal Studies
MH  - Malaria/*epidemiology/*immunology
MH  - Malaria, Falciparum/immunology
MH  - Protozoan Proteins/*immunology
MH  - Rural Population
MH  - Seasons
MH  - Splenomegaly
MH  - Sudan/epidemiology
EDAT- 2004/01/14 05:00
MHDA- 2004/03/05 05:00
CRDT- 2004/01/14 05:00
PHST- 2004/01/14 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2004/01/14 05:00 [entrez]
PST - ppublish
SO  - Bull Soc Pathol Exot. 2003 Nov;96(4):287-90.