PMID- 14718045
OWN - NLM
STAT- MEDLINE
DCOM- 20041019
LR  - 20190922
IS  - 0105-6263 (Print)
IS  - 0105-6263 (Linking)
VI  - 27
IP  - 1
DP  - 2004 Feb
TI  - Susceptibility gene for non-obstructive azoospermia in the HLA class II region: 
      correlations with Y chromosome microdeletion and spermatogenesis.
PG  - 37-41
AB  - We previously reported an association between the human leukocyte antigen (HLA) 
      haplotype DRB1*1302-DQB1*0604 in the HLA class II region and non-obstructive 
      azoospermia in Japanese men. To identify possible associations between the 
      HLA-DRB1*1302-DQB1*0604 allele in the HLA class II region and azoospermia factor 
      (AZF) deletion in the Y chromosome, we performed genomic polymerase chain 
      reaction (PCR) analysis of the AZF region. We then determined spermatogenic 
      impairment (Johnsen score) in testicular biopsy specimens from patients with or 
      without the DRB1*1302-DQB1*0604 haplotype. The AZF microdeletion rate in patients 
      with this haplotype was 3.85%, compared with 11.8% in others (no correlation). 
      However, Johnsen scores in patients with the DRB1*1302-DQB1*0604 haplotype were 
      3.13 +/- 1.34 (mean +/- SD), compared with 3.70 +/- 1.51 in others (p < 0.05). 
      While the DRB1*1302-DQB1*0604 haplotype acts independently from Y chromosome 
      deletion, the haplotype might either act directly, or be functionally related to 
      an unknown autosomal gene. In either case, this haplotype showed association with 
      severe spermatogenic impairment.
FAU - Takao, Tetsuya
AU  - Takao T
AD  - Department of Urology, Osaka University Graduate School of Medicine, 2-2 
      Yamadaoka, Suita, Osaka 565-0871, Japan.
FAU - Tsujimura, Akira
AU  - Tsujimura A
FAU - Sada, Masaharu
AU  - Sada M
FAU - Goto, Rieko
AU  - Goto R
FAU - Koga, Minoru
AU  - Koga M
FAU - Miyagawa, Yasushi
AU  - Miyagawa Y
FAU - Matsumiya, Kiyomi
AU  - Matsumiya K
FAU - Yamada, Kazuhiko
AU  - Yamada K
FAU - Takahara, Shiro
AU  - Takahara S
FAU - Okuyama, Akihiko
AU  - Okuyama A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Int J Androl
JT  - International journal of andrology
JID - 8000141
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Y
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Japan
MH  - Male
MH  - Oligospermia/*genetics
MH  - Polymerase Chain Reaction
MH  - Spermatogenesis/*genetics
EDAT- 2004/01/14 05:00
MHDA- 2004/10/20 09:00
CRDT- 2004/01/14 05:00
PHST- 2004/01/14 05:00 [pubmed]
PHST- 2004/10/20 09:00 [medline]
PHST- 2004/01/14 05:00 [entrez]
AID - 445 [pii]
AID - 10.1046/j.0105-6263.2003.00445.x [doi]
PST - ppublish
SO  - Int J Androl. 2004 Feb;27(1):37-41. doi: 10.1046/j.0105-6263.2003.00445.x.