PMID- 14719628
OWN - NLM
STAT- MEDLINE
DCOM- 20040209
LR  - 20171206
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 168
IP  - 12
DP  - 2003 Dec
TI  - Human leukocyte antigens in Gulf War veterans with chronic unexplained multiple 
      symptoms.
PG  - 1015-8
AB  - Several articles have suggested that immune dysregulation related to Gulf War 
      deployment may be involved in chronic illnesses with an unclear etiology among 
      Gulf War veterans. To determine whether genetic susceptibility related to the 
      human leukocyte antigen (HLA) system might play a role in development of the 
      veterans' illnesses, we examined the frequency distribution of HLA A, B, DR, and 
      DQ antigens from symptomatic veterans residing in south-central Pennsylvania 
      compared with a local healthy population database. Only HLA-A28 demonstrated 
      statistical significance. A28 was present in 7 (21.9%) of 32 of the veterans and 
      15 (6.9%) of 217 of the healthy population (p = 0.01, Fisher's exact test). This 
      accounts for a minority of the ill veterans tested and is not statistically 
      significant when corrected for the number of antigens determined. We conclude 
      that specific HLA antigens are not strongly associated with the illnesses of Gulf 
      War veterans.
FAU - O'Bryan, Thomas A
AU  - O'Bryan TA
AD  - Department of Medicine, Division of General Internal Medicine, Pennsylvania State 
      University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 
      17033, USA.
FAU - Romano, Paula J
AU  - Romano PJ
FAU - Zangwill, Bruce C
AU  - Zangwill BC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Chronic Disease
MH  - Female
MH  - HLA Antigens/*blood
MH  - Humans
MH  - Male
MH  - Persian Gulf Syndrome/blood/*immunology
MH  - Pilot Projects
MH  - *Veterans
MH  - Warfare
EDAT- 2004/01/15 05:00
MHDA- 2004/02/11 05:00
CRDT- 2004/01/15 05:00
PHST- 2004/01/15 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2004/01/15 05:00 [entrez]
PST - ppublish
SO  - Mil Med. 2003 Dec;168(12):1015-8.