PMID- 1472022
OWN - NLM
STAT- MEDLINE
DCOM- 19930128
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 189
IP  - 2
DP  - 1992 Dec 15
TI  - Combinatorial crosstalk of transacting factors binding to the L-type pyruvate 
      kinase promoter elements analysed in vitro.
PG  - 1119-28
AB  - Five Dnase 1 footprints, termed boxes L1 to L5, have been characterized in the 
      280 bp upstream from the cap site of the L-type pyruvate kinase (L-PK) gene. They 
      bind from 3' to 5', the factors HNF1, HNF4, MLTF, and a non-identified protein 
      referred to as L5 binding factor (L5-BF). These elements, individually or 
      variably combined, were tested by cell-free transcription. The L1 box stimulates 
      both L-PK and TK promoters, but in the context of L-PK promoter, it cooperates 
      with the L3 element to reach a high level of transcriptional activation. The L3 
      and L4 elements exhibit weaker influences, increased by homologous or 
      heterologous interactions. The L5 box behaves as a promoter-dependent negative 
      regulatory element.
FAU - Puzenat, N
AU  - Puzenat N
AD  - ICGM, Laboratoire de recherches en genetique et pathologie moleculaires, INSERM 
      U.129, universite Paris 5, CHU Cochin, France.
FAU - Vaulont, S
AU  - Vaulont S
FAU - Kahn, A
AU  - Kahn A
FAU - Raymondjean, M
AU  - Raymondjean M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hepatocyte Nuclear Factor 4)
RN  - 0 (Isoenzymes)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Phosphoproteins)
RN  - 0 (Transcription Factors)
RN  - 126548-29-6 (Hepatocyte Nuclear Factor 1)
RN  - 138674-15-4 (Hepatocyte Nuclear Factor 1-beta)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
RN  - EC 3.1.21.1 (Deoxyribonuclease I)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Brain/*enzymology
MH  - DNA-Binding Proteins/*metabolism
MH  - Deoxyribonuclease I
MH  - Hepatocyte Nuclear Factor 1
MH  - Hepatocyte Nuclear Factor 1-beta
MH  - Hepatocyte Nuclear Factor 4
MH  - Isoenzymes/*genetics
MH  - Liver/*enzymology
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*metabolism
MH  - Oligodeoxyribonucleotides
MH  - *Phosphoproteins
MH  - Plasmids
MH  - Polymerase Chain Reaction/methods
MH  - *Promoter Regions, Genetic
MH  - Pyruvate Kinase/*genetics
MH  - Sequence Deletion
MH  - Transcription Factors/*metabolism
MH  - Transcription, Genetic
EDAT- 1992/12/15 00:00
MHDA- 1992/12/15 00:01
CRDT- 1992/12/15 00:00
PHST- 1992/12/15 00:00 [pubmed]
PHST- 1992/12/15 00:01 [medline]
PHST- 1992/12/15 00:00 [entrez]
AID - 0006-291X(92)92320-W [pii]
AID - 10.1016/0006-291x(92)92320-w [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1992 Dec 15;189(2):1119-28. doi: 
      10.1016/0006-291x(92)92320-w.