PMID- 14720301 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231105 IS - 1476-8518 (Print) IS - 1476-8518 (Electronic) IS - 1476-8518 (Linking) VI - 2 IP - 1 DP - 2004 Jan 13 TI - Dendritic cells: In the forefront of immunopathogenesis and vaccine development - A review. PG - 1 AB - Dendritic cellls (DCs) comprise an essential component of the immune system. These cells, as antigen presenting cells (APCs) to naive T cells, are crucial in the initiation of antigen specific immune responses. In the past years, several DC subsets have been identified in different organs which exert different effects in order to elicit adaptive immune responses. Thus, identification of such DC subsets has led to a better understanding of their distribution and function in the body. In this review, several key properties of the immunobiology, immunopathogenesis and vaccine strategies using DCs will be discussed. FAU - Mohamadzadeh, Mansour AU - Mohamadzadeh M AD - Department of Medicine, Tulane University Health Science Center, New Orleans, USA. mzadeh@tulane.edu FAU - Luftig, Ronald AU - Luftig R LA - eng PT - Journal Article DEP - 20040113 PL - England TA - J Immune Based Ther Vaccines JT - Journal of immune based therapies and vaccines JID - 101152206 PMC - PMC324568 EDAT- 2004/01/15 05:00 MHDA- 2004/01/15 05:01 PMCR- 2004/01/13 CRDT- 2004/01/15 05:00 PHST- 2003/12/03 00:00 [received] PHST- 2004/01/13 00:00 [accepted] PHST- 2004/01/15 05:00 [pubmed] PHST- 2004/01/15 05:01 [medline] PHST- 2004/01/15 05:00 [entrez] PHST- 2004/01/13 00:00 [pmc-release] AID - 1476-8518-2-1 [pii] AID - 10.1186/1476-8518-2-1 [doi] PST - epublish SO - J Immune Based Ther Vaccines. 2004 Jan 13;2(1):1. doi: 10.1186/1476-8518-2-1.