PMID- 14722890
OWN - NLM
STAT- MEDLINE
DCOM- 20040220
LR  - 20081121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 2
DP  - 2004 Jan 15
TI  - Induction of cellular and humoral immunity after aerosol or subcutaneous 
      administration of Edmonston-Zagreb measles vaccine as a primary dose to 
      12-month-old children.
PG  - 254-7
AB  - Infants were immunized by aerosol (10(3.6) plaque-forming units [pfu]/dose) or 
      subcutaneous (sc) (10(4.27) pfu/dose) administration of Edmonston-Zagreb measles 
      vaccine. Measles-specific T cell proliferative responses with a stimulation index 
      of > or =3 developed in 72% of children given aerosol-administered vaccine, 
      compared with 87% given s.c.-administered vaccine (P =.06). Seroconversion rates 
      were 90% after aerosol-administered vaccine and 100% after s.c.-administered 
      vaccine (P=.01), and measles geometric mean titers were 237 milli-international 
      units (mIU) (95% confidence interval [CI], 146-385 mIU) and 487 mIU (95% CI, 
      390-609 mIU) in each group, respectively (P=.01). Measles-specific T and B cell 
      responses were weaker after aerosol than after sc vaccination, indicating a need 
      to use a higher aerosol dose to achieve optimal immunogenicity.
FAU - Wong-Chew, Rosa Maria
AU  - Wong-Chew RM
AD  - Dept. de Medicina Experimental, Facultad de Medicina, Universidad Nacional 
      Autonoma de Mexico, Mexico City, Mexico. rmwong@correo.unam.mx
FAU - Islas-Romero, Rocio
AU  - Islas-Romero R
FAU - Garcia-Garcia, Maria de Lourdes
AU  - Garcia-Garcia Mde L
FAU - Beeler, Judy A
AU  - Beeler JA
FAU - Audet, Susette
AU  - Audet S
FAU - Santos-Preciado, Jose Ignacio
AU  - Santos-Preciado JI
FAU - Gans, Hayley
AU  - Gans H
FAU - Lew-Yasukawa, Linda
AU  - Lew-Yasukawa L
FAU - Maldonado, Yvonne A
AU  - Maldonado YA
FAU - Arvin, Ann M
AU  - Arvin AM
FAU - Valdespino-Gomez, Jose Luis
AU  - Valdespino-Gomez JL
LA  - eng
GR  - A137127/PHS HHS/United States
GR  - HD01310/HD/NICHD NIH HHS/United States
GR  - HD33698/HD/NICHD NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040105
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Aerosols)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Measles Vaccine)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aerosols
MH  - Antibodies, Viral/blood
MH  - Female
MH  - Humans
MH  - Infant
MH  - Injections, Subcutaneous
MH  - Interferon-gamma/biosynthesis
MH  - Lymphocyte Activation
MH  - Male
MH  - Measles Vaccine/administration & dosage/*immunology
MH  - T-Lymphocytes/immunology
MH  - Vaccination
EDAT- 2004/01/15 05:00
MHDA- 2004/02/21 05:00
CRDT- 2004/01/15 05:00
PHST- 2003/03/19 00:00 [received]
PHST- 2003/07/25 00:00 [accepted]
PHST- 2004/01/15 05:00 [pubmed]
PHST- 2004/02/21 05:00 [medline]
PHST- 2004/01/15 05:00 [entrez]
AID - JID30837 [pii]
AID - 10.1086/380565 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Jan 15;189(2):254-7. doi: 10.1086/380565. Epub 2004 Jan 5.