PMID- 14725926
OWN - NLM
STAT- MEDLINE
DCOM- 20040514
LR  - 20190906
IS  - 0730-725X (Print)
IS  - 0730-725X (Linking)
VI  - 21
IP  - 10
DP  - 2003 Dec
TI  - Functional MRI using intravascular contrast agents: detrending of the relative 
      cerebrovascular (rCBV) time course.
PG  - 1191-200
AB  - In pharmacological fMRI experiments in animal models, blood pool contrast agents 
      may be used to map cerebral blood volume change as a surrogate for neural 
      activation. When the background signal drift due to contrast agent washout is 
      non-negligible over the duration of the signal changes of interest, time-course 
      detrending is essential for accurate interpretation of the experiment. Detrending 
      approaches based on estimation of the background signal from a baseline period of 
      the time course prior to pharmacological (or functional) challenge were evaluated 
      with the aim of identifying a robust method of estimating the contrast agent 
      washout contribution to the background signal drift. For fMRI studies in the rat, 
      it was found that a constrained fit of a mono-exponential washout model was more 
      accurate than a constant background approximation and unconstrained fits for 
      experiments investigating the functional response to rapid pharmacological 
      challenges such as cocaine and amphetamine. Moreover, the constrained fitting 
      approach allows shorter baseline periods than unconstrained extrapolation, 
      reducing the required duration of the experiment.
FAU - Schwarz, Adam J
AU  - Schwarz AJ
AD  - Department of Neuroimaging, Centre of Excellence for Drug Discovery (Psychiatry), 
      GlaxoSmithKline Medicines Research Centre, Verona, Italy. adam.j.schwarz@gsk.com
FAU - Reese, Torsten
AU  - Reese T
FAU - Gozzi, Alessandro
AU  - Gozzi A
FAU - Bifone, Angelo
AU  - Bifone A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Oxides)
RN  - 0 (Suspensions)
RN  - CK833KGX7E (Amphetamine)
RN  - E1UOL152H7 (Iron)
RN  - G6N3J05W84 (ferumoxides)
RN  - I5Y540LHVR (Cocaine)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Amphetamine
MH  - Animals
MH  - Blood Volume
MH  - Brain/drug effects/physiopathology
MH  - *Cerebrovascular Circulation
MH  - Cocaine
MH  - *Contrast Media
MH  - Dextrans
MH  - Ferrosoferric Oxide
MH  - Iron
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetite Nanoparticles
MH  - Male
MH  - Oxides
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Suspensions
MH  - Time Factors
EDAT- 2004/01/17 05:00
MHDA- 2004/05/15 05:00
CRDT- 2004/01/17 05:00
PHST- 2004/01/17 05:00 [pubmed]
PHST- 2004/05/15 05:00 [medline]
PHST- 2004/01/17 05:00 [entrez]
AID - S0730725X03003308 [pii]
AID - 10.1016/j.mri.2003.08.020 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2003 Dec;21(10):1191-200. doi: 10.1016/j.mri.2003.08.020.