PMID- 14726996
OWN - NLM
STAT- MEDLINE
DCOM- 20041122
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 173
IP  - 3-4
DP  - 2004 May
TI  - Effect of ambient temperature and a prior neurotoxic dose of 
      3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to 
      a single or repeated ('binge' ingestion) low dose of MDMA.
PG  - 264-9
AB  - RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) administration to 
      rats produces acute hyperthermia and long-term neurotoxic damage to 
      5-hydroxytryptamine (serotonin, 5-HT) neurones. OBJECTIVE: We wished to examine 
      MDMA-induced hyperthermia in rats housed at normal (19 degrees C) and high (30 
      degrees C) room temperatures and investigate the effect of a prior neurotoxic 
      lesion. METHODS: Rectal temperature was measured after administration of single 
      or repeated doses of MDMA to rats housed at 19 degrees C and 30 degrees C. 
      RESULTS: MDMA (5 mg/kg i.p.) produced a sustained hyperthermic response in rats 
      housed at 30 degrees C, but not in rats housed at 19 degrees C. A prior (5 weeks 
      earlier) neurotoxic dose of MDMA (12.5 mg/kg i.p.) resulted in MDMA (5 mg/kg) 
      producing a greater hyperthermic response in rats housed at 30 degrees C than in 
      non-pre-treated animals. Repeated MDMA administration (binge dosing; 2, 4 or 6 
      mg/kg x3) produced dose-dependent hyperthermia in rats housed at 19 degrees C, 
      with MDMA (2 mg/kg x3) having little effect. However, this dose produced 
      significant hyperthermia (> or =2 degrees C above control values)in rats housed 
      at 30 degrees C following the third dose. A prior neurotoxic dose of MDMA 
      resulted in MDMA (2 mg/kg x3) producing marked hyperthermia (>1 degrees C) after 
      the first dose and severe hyperthermia (> or =2 degrees C) after the third dose. 
      CONCLUSIONS: MDMA administration to rats housed at 30 degrees C produces a more 
      severe hyperthermic response than that seen in rats housed at 19 degrees C. A 
      prior neurotoxic dose enhances the response further in animals housed at 30 
      degrees C. Binge dosing produces a higher final peak response than a similar 
      non-divided dose. This effect is more marked in animals housed at high room 
      temperature. These data may have implications for recreational users of MDMA in 
      hot environments, particularly those who may have damaged serotoninergic neurones 
      because of prior heavy or frequent use of the drug.
FAU - Green, A Richard
AU  - Green AR
AD  - Neuropharmacology Research Group, School of Pharmacy, De Montfort University, The 
      Gateway, Leicester, LE1 9BH, UK. richard.green@astrazeneca.com
FAU - Sanchez, Veronica
AU  - Sanchez V
FAU - O'Shea, Esther
AU  - O'Shea E
FAU - Saadat, Kathryn S
AU  - Saadat KS
FAU - Elliott, J Martin
AU  - Elliott JM
FAU - Colado, M Isabel
AU  - Colado MI
LA  - eng
PT  - Journal Article
DEP - 20040115
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Dose-Response Relationship, Drug
MH  - *Heating
MH  - Hypothermia/*chemically induced
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/*toxicity
MH  - Rats
MH  - Serotonin Agents/*administration & dosage/*toxicity
EDAT- 2004/01/17 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/01/17 05:00
PHST- 2003/07/24 00:00 [received]
PHST- 2003/11/10 00:00 [accepted]
PHST- 2004/01/17 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/01/17 05:00 [entrez]
AID - 10.1007/s00213-003-1725-2 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2004 May;173(3-4):264-9. doi: 
      10.1007/s00213-003-1725-2. Epub 2004 Jan 15.