PMID- 14728273 OWN - NLM STAT- MEDLINE DCOM- 20041214 LR - 20181113 IS - 1942-597X (Electronic) IS - 1559-4076 (Linking) VI - 2003 DP - 2003 TI - Detection of outbreaks from time series data using wavelet transform. PG - 748-52 AB - In this paper, we developed a new approach to detection of disease outbreaks based on wavelet transform. It is capable of dealing with two problems found in real-world time series data, namely, negative singularity and long-term trends, which may degrade the performance of current approaches to outbreak detection. To test this approach, we introduced artificail disease outbreaks and negative singularities into a real world dataset and applied it and two other algorithms-autoregressive (AR) and Multi-resolution Wavelet Auto-regressive (MWAR) - to this dataset. We compared the performance of these algorithms in terms of sensitivity, specificity and timeliness. The results showed that our approach had similar sensitivity and specificity and slightly better timeliness compared to the other two algorithms. When we introduced negative singularities, its performance did not degrade as much as the other two algorithms' performance. We conclude that our approach to detection, when compared to traditional approaches, may not be as susceptible to degradation of performance caused by negative singularities. FAU - Zhang, Jun AU - Zhang J AD - Center of Biomedical Informatics, University of Pittsburgh, PA 15260, USA. FAU - Tsui, Fu -Chiang AU - Tsui F- FAU - Wagner, Michael M AU - Wagner MM FAU - Hogan, William R AU - Hogan WR LA - eng GR - GO8 LM06625-01/LM/NLM NIH HHS/United States GR - T15 LM/DE07059/LM/NLM NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - AMIA Annu Symp Proc JT - AMIA ... Annual Symposium proceedings. AMIA Symposium JID - 101209213 SB - IM MH - *Algorithms MH - *Disease Outbreaks MH - Humans MH - Mathematical Computing MH - Models, Biological MH - ROC Curve PMC - PMC1479935 EDAT- 2004/01/20 05:00 MHDA- 2004/12/16 09:00 PMCR- 2003/01/01 CRDT- 2004/01/20 05:00 PHST- 2004/01/20 05:00 [pubmed] PHST- 2004/12/16 09:00 [medline] PHST- 2004/01/20 05:00 [entrez] PHST- 2003/01/01 00:00 [pmc-release] AID - D030003618 [pii] AID - 152 [pii] PST - ppublish SO - AMIA Annu Symp Proc. 2003;2003:748-52.