PMID- 14728861
OWN - NLM
STAT- MEDLINE
DCOM- 20040226
LR  - 20081121
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 38
IP  - 10
DP  - 2003 Oct
TI  - [Study on the association between maternal-infantile vertical transmission of 
      hepatitis B virus and human leukocyte antigen DR gene domain].
PG  - 599-603
AB  - OBJECTIVE: To study on the association between maternal-infantile vertical 
      transmission of hepatitis B virus and human leukocyte antigen (HLA)-DR gene 
      domain. METHODS: HLA-DR3, HLA-DR4, HLA-DR13, HLA-DR15 were detected by the 
      technique of polymerase chain reaction-sequence specific primers (PCR-SSP) in 
      maternal and neonatal blood of study group (78 cases) and control group (40 
      cases). RESULTS: (1) In the pregnant women of study group, the gene frequency of 
      HLA-DR3 was significantly higher than that in control group (P < 0.05), but the 
      frequency of HLA-DR13 was significantly lower than those in control group (P < 
      0.05), while the frequencies of HLA-DR4 and HLA-DR15 had no significant 
      difference between the two groups (P > 0.05). (2) The pregnant women with high 
      replication condition of HBV had significantly higher frequency of HLA-DR3 than 
      those with low replication of HBV (P < 0.05). There was no significant difference 
      of other phenotype between the two conditions. (3) The frequency of HLA-DR3 of 
      pregnant women in intrauterine infection group was significantly higher than that 
      of intrauterine non-infection group (P < 0.05). There had no significant 
      difference of the frequencies of HLA-DR4, HLA-DR13, HLA-DR15 between the two 
      groups (P > 0.05). The gene frequencies of HLA-DR3, HLA-DR4, HLA-DR13, HLA-DR15 
      were found no significant difference between the neonates of the study group and 
      the control group (P > 0.05). Although the gene frequency of HLA-DR3 (30.0%) in 
      neonates of intrauterine infection group was higher than that of intrauterine 
      non-infection group (7.4%), but no statistical difference was found between the 
      two group (P > 0.05). CONCLUSIONS: HLA-DR3 is positively correlated with chronic 
      HBV carrying and high replication conditions of pregnant women. HLA-DR13 
      correlated negatively with chronic HBV carrying of the pregnant women. HLA-DR3 
      carriers of pregnant women and their fetuses have a susceptibility of HBV 
      infection.
FAU - Liu, Hai-ying
AU  - Liu HY
AD  - Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 
      Jinan 250012, China.
FAU - Kong, Bei-hua
AU  - Kong BH
FAU - Luo, Xia
AU  - Luo X
FAU - Xu, Yong-ping
AU  - Xu YP
FAU - Dai, Min-sheng
AU  - Dai MS
FAU - Jiang, Sen
AU  - Jiang S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - Hepatitis B/genetics/immunology/*transmission
MH  - Humans
MH  - *Infectious Disease Transmission, Vertical
MH  - Polymerase Chain Reaction
MH  - Pregnancy
EDAT- 2004/01/20 05:00
MHDA- 2004/02/27 05:00
CRDT- 2004/01/20 05:00
PHST- 2004/01/20 05:00 [pubmed]
PHST- 2004/02/27 05:00 [medline]
PHST- 2004/01/20 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 2003 Oct;38(10):599-603.