PMID- 14729159
OWN - NLM
STAT- MEDLINE
DCOM- 20040901
LR  - 20220317
IS  - 0378-3782 (Print)
IS  - 0378-3782 (Linking)
VI  - 76
IP  - 1
DP  - 2004 Jan
TI  - Perinatal changes of brain-derived neurotrophic factor in pre- and fullterm 
      neonates.
PG  - 17-22
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is abundant in brain and 
      peripheral nerves, affects normal development, growth and survival and is 
      implicated in immune response. AIM: To determine in single preterm (P) and 
      fullterm (F) neonates, circulating intra- and extrauterine levels of BDNF, 
      supposingly reflecting their neuronal and immune maturity. STUDY DESIGN: 
      Prospective study. SUBJECTS: Thirty healthy, appropriate for gestational age 
      (AGA) F (mean gestational age 39.2+/-1.4 weeks), 15 healthy AGA P (29.4+/-1.3 
      weeks), and their mothers. OUTCOME MEASURES: BDNF was measured by enzyme 
      immunoassay methods in the serum of: mothers at the first stage of labor (MS), 
      the umbilical cord (UC) and the neonates on days 1 (N1) and 4 (N4) postpartum. 
      RESULTS: Levels of BDNF in (a). FMS did not differ from PMS, but both were 
      significantly higher than respective (F or P) UC, N1 and N4 (p ranging from <0.01 
      to <0.001), (b). FUC, FN1 and FN4 were significantly higher than PUC (p<0.001), 
      PN1 (p<0.03) and PN4 (p<0.02), respectively, (c). PN1 increased significantly as 
      compared to PUC (p<0.05). CONCLUSIONS: Higher BDNF MS levels may reflect the 
      mature nervous and immune systems of mothers. Higher BDNF levels in F than P may 
      also be due to advanced maturity in the former. Increased BDNF levels in PN1 as 
      compared to PUC may indicate stimulation of immune response with exposure to 
      antigenic stimuli from the extrauterine environment. Nevertheless, this 
      stimulation is insufficient in P, who by decreasing N4 levels are by far less 
      protected than F.
FAU - Malamitsi-Puchner, Ariadne
AU  - Malamitsi-Puchner A
AD  - 2nd Department of Obstetrics and Gynecology, University of Athens, 19, Soultani 
      str, GR-10682, Athens, Greece. malamitsi@aias.gr
FAU - Economou, Emmanuel
AU  - Economou E
FAU - Rigopoulou, Ourania
AU  - Rigopoulou O
FAU - Boutsikou, Theodora
AU  - Boutsikou T
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn/*blood
MH  - Infant, Premature/*blood
MH  - Male
MH  - Maternal Age
MH  - Postpartum Period
MH  - Pregnancy/*blood
MH  - Pregnancy, High-Risk
MH  - Prospective Studies
EDAT- 2004/01/20 05:00
MHDA- 2004/09/02 05:00
CRDT- 2004/01/20 05:00
PHST- 2004/01/20 05:00 [pubmed]
PHST- 2004/09/02 05:00 [medline]
PHST- 2004/01/20 05:00 [entrez]
AID - S0378378203001646 [pii]
AID - 10.1016/j.earlhumdev.2003.10.002 [doi]
PST - ppublish
SO  - Early Hum Dev. 2004 Jan;76(1):17-22. doi: 10.1016/j.earlhumdev.2003.10.002.