PMID- 14730086
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20181211
IS  - 1230-6002 (Print)
IS  - 1230-6002 (Linking)
VI  - 55
IP  - 6
DP  - 2003 Nov-Dec
TI  - Potential antidepressant activity of sigma ligands.
PG  - 923-34
AB  - Despite many years' studies of antidepressant drugs (ADs), their mechanism of 
      action still remains unclear. Recently, it has been postulated that substances 
      capable of reducing neurotransmission at the NMDA complex may represent a new 
      class of ADs. Since several ADs have a high affinity for sigma receptors, the 
      sigma binding site may be a relevant mechanism in antidepressant action. 
      Moreover, sigma ligands are able to modulate the activity of the central 
      neurotransmitter systems, including noradrenergic, serotonergic, dopaminergic and 
      glutamatergic (NMDA) ones, which are seemingly important for the mechanism of 
      action of known ADs. The existence of at least two different subtypes of sigma 
      receptors, denoted sigma1 and sigma2 is now widely accepted. The selective 
      agonists of both sigma receptor subtypes are available at present. In particular, 
      a potential antidepressant activity of sigma1 receptor agonists has been 
      postulated, since the antidepressive-like actions of these compounds have been 
      shown in animal models. This article reviews the findings related to potential 
      antidepressant activity of new, selective sigma ligands.
FAU - Skuza, Grazyna
AU  - Skuza G
AD  - Department of Pharmacology, Institute of Pharmacology, Polish Academy of 
      Sciences, Smetna 12, PL 31-343 Krakow, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Pol J Pharmacol
JT  - Polish journal of pharmacology
JID - 9313882
RN  - 0 
      (1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Cinnamates)
RN  - 0 (Cyclopropanes)
RN  - 0 (Ligands)
RN  - 0 (Piperazines)
RN  - 0 (Quinolones)
RN  - 0 (Receptors, sigma)
RN  - 9J7A4144BX (SA 4503)
RN  - XA3745J38K (igmesine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Cinnamates/pharmacology
MH  - Cyclopropanes/pharmacology
MH  - Humans
MH  - Ligands
MH  - Piperazines/pharmacology
MH  - Quinolones/pharmacology
MH  - Receptors, sigma/*agonists/*metabolism/physiology
RF  - 98
EDAT- 2004/01/20 05:00
MHDA- 2004/06/16 05:00
CRDT- 2004/01/20 05:00
PHST- 2003/09/30 00:00 [received]
PHST- 2003/11/04 00:00 [revised]
PHST- 2004/01/20 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2004/01/20 05:00 [entrez]
PST - ppublish
SO  - Pol J Pharmacol. 2003 Nov-Dec;55(6):923-34.