PMID- 14730194
OWN - NLM
STAT- MEDLINE
DCOM- 20040308
LR  - 20131121
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 49
IP  - 1
DP  - 2004
TI  - Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms 
      with Alzheimer's disease and age of onset.
PG  - 10-2
AB  - Because of a decrease in central brain-derived neurotrophic factor (BDNF) levels 
      in Alzheimer's disease (AD) and the important role of BDNF in neuronal survival, 
      BDNF may represent a candidate gene conferring susceptibility to AD. Recently, a 
      functional BDNF Val66Met polymorphism has been associated with AD in an Italian 
      population. In the present study, we investigated a possible role of this BDNF 
      polymorphism in the susceptibility of AD or AD onset in a Chinese population. 
      Comparing AD patients and controls, the distribution of the BDNF genotypes and 
      alleles did not differ significantly. The onset age was not significantly 
      different comparing the three BDNF genotype groups. Our negative findings suggest 
      that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the 
      pathogenesis of AD in the Chinese population and do not support previous findings 
      that homozygosity for the 66Val allele confers an increased risk for AD. Further 
      studies with genetic variations in BDNF relating either to AD-associated 
      depression or to the AD treatment response are suggested.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
AD  - Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. 
      sjtsai@vghtpe.gov.tw
FAU - Hong, Chen-Jee
AU  - Hong CJ
FAU - Liu, Hsiu-Chih
AU  - Liu HC
FAU - Liu, Tsung-Yun
AU  - Liu TY
FAU - Hsu, Li-En
AU  - Hsu LE
FAU - Lin, Ching-Hua
AU  - Lin CH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - *Age of Onset
MH  - Aged
MH  - Alleles
MH  - Alzheimer Disease/*genetics/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - *Polymorphism, Genetic
MH  - Valine/genetics
EDAT- 2004/01/20 05:00
MHDA- 2004/03/09 05:00
CRDT- 2004/01/20 05:00
PHST- 2004/01/20 05:00 [pubmed]
PHST- 2004/03/09 05:00 [medline]
PHST- 2004/01/20 05:00 [entrez]
AID - 75332 [pii]
AID - 10.1159/000075332 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2004;49(1):10-2. doi: 10.1159/000075332.