PMID- 14730702
OWN - NLM
STAT- MEDLINE
DCOM- 20040319
LR  - 20200422
IS  - 0894-1491 (Print)
IS  - 1098-1136 (Electronic)
IS  - 0894-1491 (Linking)
VI  - 45
IP  - 3
DP  - 2004 Feb
TI  - Induction of chemokines in human astrocytes by picornavirus infection requires 
      activation of both AP-1 and NF-kappa B.
PG  - 287-96
AB  - Infection with different picornaviruses can cause meningitis/encephalitis in 
      humans and experimental animals. To investigate the mechanisms of such 
      inflammatory diseases, potential chemokine gene activation in human astrocytes 
      was investigated following infection with Theiler's murine encephalomyelitis 
      virus (TMEV), coxsackievirus B3 (CVB3), or coxsackievirus B4 (CVB4). We report 
      that all these viruses are potent inducers for the expression of interleukin-8 
      (IL-8) and monocyte chemoattractant protein-1 (MCP-1) genes in primary human 
      astrocytes, as well as in an established astrocyte cell line (U-373MG). Further 
      studies indicated that both activator protein-1 (AP-1) and NF-kappaB 
      transcription factors are required in the activation of chemokine genes in human 
      astrocytes infected with various picornaviruses. Interestingly, the pattern of 
      activated chemokine genes in human astrocytes is quite restricted compared to 
      that in mouse astrocytes infected with the same viruses, suggesting species 
      differences in gene activation. This may result in potential differences in the 
      pathogenic outcome in each species.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Kwon, Daeho
AU  - Kwon D
AD  - Department of Microbiology and Immunology, Northwestern University Feinberg 
      Medical School, Chicago, Illinois 60611, USA.
FAU - Fuller, Alyson C
AU  - Fuller AC
FAU - Palma, Joann P
AU  - Palma JP
FAU - Choi, In-Hong
AU  - Choi IH
FAU - Kim, Byung S
AU  - Kim BS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Chemokines)
RN  - 0 (NF-kappa B)
RN  - 0 (Transcription Factor AP-1)
SB  - IM
MH  - Animals
MH  - Astrocytes/enzymology/immunology/*metabolism/*virology
MH  - Cell Line
MH  - Chemokines/*biosynthesis
MH  - Enterovirus B, Human/*physiology
MH  - Humans
MH  - Mice
MH  - NF-kappa B/antagonists & inhibitors/*metabolism
MH  - Theilovirus/*physiology
MH  - Transcription Factor AP-1/*metabolism
PMC - PMC7165560
EDAT- 2004/01/20 05:00
MHDA- 2004/03/20 05:00
PMCR- 2003/12/11
CRDT- 2004/01/20 05:00
PHST- 2004/01/20 05:00 [pubmed]
PHST- 2004/03/20 05:00 [medline]
PHST- 2004/01/20 05:00 [entrez]
PHST- 2003/12/11 00:00 [pmc-release]
AID - GLIA10331 [pii]
AID - 10.1002/glia.10331 [doi]
PST - ppublish
SO  - Glia. 2004 Feb;45(3):287-96. doi: 10.1002/glia.10331.