PMID- 14732793
OWN - NLM
STAT- MEDLINE
DCOM- 20040617
LR  - 20171101
IS  - 0025-7931 (Print)
IS  - 0025-7931 (Linking)
VI  - 70
IP  - 6
DP  - 2003 Nov-Dec
TI  - Acute phase reactants and cytokine levels in unilateral community-acquired 
      pneumonia.
PG  - 615-22
AB  - BACKGROUND: Bacterial infection of the lower respiratory tract initiates an acute 
      inflammatory response. Regulation of the inflammatory response in bacterial 
      pneumonia depends on a complex interaction between immune cells and inflammatory 
      cytokines. OBJECTIVES: We investigated the initial levels of proinflammatory 
      cytokines and acute phase reactants (APR), e.g. C-reactive protein (CRP), upon 
      presentation of community-acquired pneumonia (CAP) in relation to clinical and 
      laboratory indices of infection. METHODS: We prospectively studied 28 consecutive 
      patients with unilateral CAP. Tumor necrosis factor-alpha (TNF-alpha), 
      interleukin (IL)-1beta, IL-6 and IL-8 concentrations were measured by ELISA in 
      both bronchoalveolar lavage (BAL) fluid and serum. RESULTS: The concentrations of 
      IL1-beta and IL-6 in BAL fluid were found to be significantly higher in the 
      involved lung than those in either the uninvolved lung (p = 0.008 and p = 0.012, 
      respectively) or serum (p = 0.002 and p = 0.025, respectively). Serum CRP 
      concentrations were increased compared to those in the involved and uninvolved 
      lung in BAL fluid (p = 0.000 and p = 0.000, respectively). In serum and BAL from 
      involved lung, IL-6 concentrations were higher in the systemic inflammatory 
      response syndrome (SIRS) group than in the non-SIRS group (p < 0.05), whereas 
      CRP, TNF-alpha, IL-1beta and IL-8 concentrations showed no difference between 
      SIRS and non-SIRS. There was no significant correlation between the acute 
      physiology and chronic health evaluation II score and the cytokines. CONCLUSIONS: 
      Our results indicate that the CRP level is higher in the serum than in the BAL 
      fluid in the lung, and that IL-6 is the most important cytokine for the 
      determination of the severity of the disease.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Kolsuz, Mustafa
AU  - Kolsuz M
AD  - Tuberculosis Control Dispensary, Osmangazi University Medical Faculty, Eskisehir, 
      Turkey. mustafakolsuz@hotmail.com
FAU - Erginel, Sinan
AU  - Erginel S
FAU - Alatas, Ozkan
AU  - Alatas O
FAU - Alatas, Fusun
AU  - Alatas F
FAU - Metintas, Muzaffer
AU  - Metintas M
FAU - Ucgun, Irfan
AU  - Ucgun I
FAU - Harmanci, Emel
AU  - Harmanci E
FAU - Colak, Omer
AU  - Colak O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 0 (Cytokines)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - APACHE
MH  - Adult
MH  - Body Temperature
MH  - Bronchoalveolar Lavage Fluid/*chemistry
MH  - C-Reactive Protein/*analysis
MH  - Community-Acquired Infections/*immunology
MH  - Cytokines/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Leukocyte Count
MH  - Lung/immunology
MH  - Male
MH  - Middle Aged
MH  - Pneumonia/*immunology
MH  - Prospective Studies
EDAT- 2004/01/21 05:00
MHDA- 2004/06/18 05:00
CRDT- 2004/01/21 05:00
PHST- 2002/03/22 00:00 [received]
PHST- 2003/06/03 00:00 [accepted]
PHST- 2004/01/21 05:00 [pubmed]
PHST- 2004/06/18 05:00 [medline]
PHST- 2004/01/21 05:00 [entrez]
AID - 75208 [pii]
AID - 10.1159/000075208 [doi]
PST - ppublish
SO  - Respiration. 2003 Nov-Dec;70(6):615-22. doi: 10.1159/000075208.