PMID- 1473313
OWN - NLM
STAT- MEDLINE
DCOM- 19930129
LR  - 20151119
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 11
IP  - 6
DP  - 1992 Nov-Dec
TI  - Immunohistochemical characterization of pineocytomas.
PG  - 298-303
AB  - The immunoreactivity of a panel of poly- and monoclonal antibodies raised against 
      different neuronal and glial antigens, was studied in paraffin-embedded specimens 
      of five pineocytomas. Antibodies against neuron-specific enolase (NSE), S-100 
      protein, neurofilaments protein (NFP), glial fibrillar acidic protein (GFAP), 
      myelin basic protein (MBP), Synaptophysin (SYN) and vimentin were used. NSE 
      immunoreactivity was detectable in nearly all tumoral cells. S-100 expression was 
      present in all tumors, but a significant variation in the number of S-100 
      positive cells was noted in the different specimens; they ranged from 3% of S-100 
      positive cells in some areas of case 1, to 30% in other areas of case 4. The 
      number of GFAP-positive cells detected in four of the five tumors was minimal. In 
      the remaining tumor, 10% to 14% the positively GFAP antisera-stained cells could 
      be seen in some areas; this tumor was considered a pineocytoma with astrocytic 
      differentiation. MBP immunoreactivity was found in isolated cells only in one 
      tumor. Neurofilaments or vimentin expression could not be found in tumoral cells. 
      Synaptophysin was studied in two tumors (cases 4 and 5). Both tumors showed a 
      fine granular neuropil pattern of immunoreactivity, but only in isolated cells of 
      case 5, occasional cytoplasmic positivity could be determined. Based upon our 
      results we can conclude that NSE and synaptophysin are markers that may be 
      applied in the diagnosis of pineocytomas. Further, our results support the 
      hypothesis that the tumoral cells in these neoplasms are of neuroendocrine 
      origin.
FAU - Coca, S
AU  - Coca S
AD  - Department of Pathology, Air Forces Hospital, Complutensis University, Madrid, 
      Spain.
FAU - Vaquero, J
AU  - Vaquero J
FAU - Escandon, J
AU  - Escandon J
FAU - Moreno, M
AU  - Moreno M
FAU - Peralba, J
AU  - Peralba J
FAU - Rodriguez, J
AU  - Rodriguez J
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (S100 Proteins)
RN  - 0 (Synaptophysin)
RN  - 0 (Vimentin)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers, Tumor/*analysis
MH  - Brain Neoplasms/*pathology
MH  - Child
MH  - Female
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Neurofilament Proteins/analysis
MH  - Phosphopyruvate Hydratase/analysis
MH  - Pineal Gland/*pathology
MH  - Pinealoma/*pathology
MH  - S100 Proteins/analysis
MH  - Synaptophysin/analysis
MH  - Vimentin/analysis
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PST - ppublish
SO  - Clin Neuropathol. 1992 Nov-Dec;11(6):298-303.