PMID- 14734093
OWN - NLM
STAT- MEDLINE
DCOM- 20040722
LR  - 20161019
IS  - 0188-4409 (Print)
IS  - 0188-4409 (Linking)
VI  - 34
IP  - 6
DP  - 2003 Nov-Dec
TI  - Hematopoietic cell transplantation: five decades of progress.
PG  - 528-44
AB  - During the past 50 years, the role of allogeneic hematopoietic cell 
      transplantation (HCT) has changed from a desperate therapeutic maneuver plagued 
      by apparently insurmountable complications to a curative treatment modality for 
      thousands of patients with hematologic diseases. Now, cure rates following human 
      leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some 
      otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or 
      thalassemia. In addition, the recent development of non-myeloablative 
      conditioning and stem cell transplantation has opened the way to include elderly 
      patients with a wide variety of hematologic malignancies. Further progress in 
      adoptive transfer of T cell populations with relative tumor specificity would 
      make the transplant procedure more effective and would extend the use of 
      allogeneic HCT for treatment of non-hematopoietic malignancies.
FAU - Baron, Frederic
AU  - Baron F
AD  - Transplantation Biology Program, Clinical Research Division, Fred Hutchinson 
      Cancer Research Center, Seattle, WA 98109-1024, USA.
FAU - Storb, Rainer
AU  - Storb R
FAU - Little, Marie-Terese
AU  - Little MT
LA  - eng
GR  - HL36444/HL/NHLBI NIH HHS/United States
GR  - CA 15704/CA/NCI NIH HHS/United States
GR  - U54 HD47175/HD/NICHD NIH HHS/United States
GR  - CA 78902/CA/NCI NIH HHS/United States
GR  - DK 42716/DK/NIDDK NIH HHS/United States
GR  - P01 CA078902/CA/NCI NIH HHS/United States
GR  - CA 18029/CA/NCI NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Graft vs Host Disease
MH  - HLA Antigens/immunology/metabolism
MH  - Hematologic Diseases/*therapy
MH  - *Hematopoietic Stem Cell Transplantation/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Transplantation Chimera
MH  - Transplantation Conditioning
MH  - Transplantation Immunology
MH  - *Transplantation, Homologous/history
RF  - 128
EDAT- 2004/01/22 05:00
MHDA- 2004/07/23 05:00
CRDT- 2004/01/22 05:00
PHST- 2004/01/22 05:00 [pubmed]
PHST- 2004/07/23 05:00 [medline]
PHST- 2004/01/22 05:00 [entrez]
AID - S0188-4409(03)00131-0 [pii]
AID - 10.1016/j.arcmed.2003.09.010 [doi]
PST - ppublish
SO  - Arch Med Res. 2003 Nov-Dec;34(6):528-44. doi: 10.1016/j.arcmed.2003.09.010.