PMID- 14734202
OWN - NLM
STAT- MEDLINE
DCOM- 20040908
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 340
IP  - 1-2
DP  - 2004 Feb
TI  - Effects of vitamin E on oxidative stress and membrane fluidity in brain of 
      streptozotocin-induced diabetic rats.
PG  - 107-15
AB  - BACKGROUND: Diabetics and experimental animal models exhibit high oxidative 
      stress due to persistent and chronic hyperglycemia, thereby deplete the activity 
      of the antioxidative defense system and thereby promote the generation of free 
      radicals. The current study examined the effects of vitamin E on oxidative stress 
      and membrane fluidity in the brain of diabetes-induced rats. METHODS: 
      Sprague-Dawley male rats were randomly assigned to normal and streptozotocin 
      (STZ)-induced diabetic groups. The diabetic groups were fed a vitamin E-free 
      diet, 40 mg vitamin E/kg diet, or 400 mg vitamin E/kg diet. Diabetes was induced 
      with STZ after 3 weeks of the experimental diet, then the rats were sacrificed 9 
      days later to determine the oxidative stress and cell membrane fluidity in the 
      brain. RESULTS: Dietary vitamin E strengthened the antioxidative defense system 
      with an increased activity of the antioxidant enzymes, such as superoxide 
      dismutase (SOD) and glutathione peroxidase (GSH-px) and increased vitamin E 
      content, in the brain of the diabetes-induced experimental rats. Accordingly, 
      vitamin E was found to reduce the accumulation of reactive oxygen species (ROS), 
      such as superoxide radical decrease the generation of oxidative damage 
      substances, such as the carbonyl value, increase the membrane fluidity lowered by 
      oxidative damage, and significantly improve the lipid composition. CONCLUSIONS: 
      Vitamin E was found to be excellent for strengthening the antioxidative defense 
      system, reducing the generation of ROS and damaging oxidative substances, and 
      maintaining membrane fluidity in the brain of diabetes-induced rats.
FAU - Hong, Jung-Hee
AU  - Hong JH
AD  - Department of Food Science and Nutrition, Catholic University of Daegu, 
      Gyeongsan-si, Gyeongbuk 712-702, South Korea.
FAU - Kim, Mi-Ji
AU  - Kim MJ
FAU - Park, Mo-Ra
AU  - Park MR
FAU - Kwag, Oh-Gye
AU  - Kwag OG
FAU - Lee, In-Seon
AU  - Lee IS
FAU - Byun, Boo Hyeong
AU  - Byun BH
FAU - Lee, Soo-Chun
AU  - Lee SC
FAU - Lee, Kyung-Bok
AU  - Lee KB
FAU - Rhee, Soon-Jae
AU  - Rhee SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Antioxidants)
RN  - 0 (Phospholipids)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Triglycerides)
RN  - 1406-18-4 (Vitamin E)
RN  - 5W494URQ81 (Streptozocin)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage/*pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Cholesterol/metabolism
MH  - Diabetes Mellitus, Experimental/chemically induced/*metabolism/*pathology
MH  - Male
MH  - Membrane Fluidity/*drug effects
MH  - Oxidative Stress/*drug effects/physiology
MH  - Phospholipids/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reactive Oxygen Species/metabolism
MH  - Streptozocin/pharmacology
MH  - Triglycerides/metabolism
MH  - Vitamin E/administration & dosage/*pharmacology
EDAT- 2004/01/22 05:00
MHDA- 2004/09/09 05:00
CRDT- 2004/01/22 05:00
PHST- 2004/01/22 05:00 [pubmed]
PHST- 2004/09/09 05:00 [medline]
PHST- 2004/01/22 05:00 [entrez]
AID - S0009898103004601 [pii]
AID - 10.1016/j.cccn.2003.10.003 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2004 Feb;340(1-2):107-15. doi: 10.1016/j.cccn.2003.10.003.