PMID- 1473653
OWN - NLM
STAT- MEDLINE
DCOM- 19930204
LR  - 20161123
IS  - 0046-5968 (Print)
IS  - 0046-5968 (Linking)
VI  - 22
IP  - 7
DP  - 1992 Jul
TI  - [Myocardial scintigraphy with Tc-99m-teboroxime: its feasibility and the 
      evaluation of its diagnostic reliability. A comparison with thallium-201 and 
      coronary angiography].
PG  - 795-805
AB  - BACKGROUND: Tc-99m-teboroxime is a new tracer for myocardial perfusion 
      scintigraphy. Its more remarkable features are the high myocardial extraction 
      fraction, which is well correlated with the coronary blood flow, and the 
      extremely rapid myocardial washout. This makes it necessary to complete the image 
      collection shortly after the injection; on the other hand, repeated scans can be 
      easily performed by renewed Tc-99m-teboroxime administrations. The aim of the 
      present study was to test the feasibility of Tc-99m-teboroxime imaging and to 
      evaluate its accuracy by comparing it with thallium-201 (TI-201) scintigraphy and 
      coronary angiography. METHODS: The patient population included 16 male patients 
      (mean age 57.8 +/- 6.3 years) affected by suspect effort angina and/or with signs 
      of exercise-induced ischemia; 12 of them had history of previous myocardial 
      infarction. They underwent effort TI-201 and Tc-99m-teboroxime myocardial 
      scintigraphy within 48 hours; left heart catheterization and coronary angiography 
      were performed within 5 days. Scintigraphic images were collected in 3 planar 
      views; each projection was divided in 3 segments, with the apical one shared by 
      all views, for a total of 7 segments/study. Tracer uptake was qualitatively 
      assessed and graduated according to a scoring scheme (from 0 = normal through 4 = 
      absent uptake). RESULTS: Tc-99m-teboroxime scans could be accomplished without 
      major problems in all subjects. The image quality was comparable to TI-201 in 8 
      patients and poorer in the remaining 8. Coronary angiography showed 50% 
      obstructions in 15 patients; of them 1 subject had a normal scintigraphic pattern 
      with both TI-201 and Tc-99m-teboroxime. The presence of previous infarction was 
      recognized by both tracers in the 12 patients with infarct history. The number of 
      abnormal segments and the uptake score were not significantly different in the 
      Tc-99m-teboroxime rest and in the TI-201 redistribution images (segments: 2.8 +/- 
      1.4 vs 2.8 +/- 1.6; score: 5.6 +/- 4.2 vs 6 +/- 4.5). The diagnosis of effort 
      ischemia was made in 13 patients with Tc-99m-teboroxime and in 12 patients with 
      TI-201. The number of abnormal segments in the exercise Tc-99m-teboroxime and 
      TI-201 myocardial scintigraphy was not significantly different (3.3 +/- 1.3 vs 
      3.3 +/- 1.5); on the contrary the defect score was significantly higher with 
      Tc-99m-teboroxime than with TI-201 (9.5 +/- 4.3 vs 8.4 +/- 4.6, p < 0.03). 
      Therefore the ischemic score (exercise defect score minus rest defect score) of 
      Tc-99m-teboroxime was significantly higher than that of TI-201 (3.9 +/- 2.8 vs 
      2.4 +/- 2.2, p < 0.02). The two tracers gave comparable results in terms of 
      recognition of patients with one-vessel or multi-vessel coronary artery disease. 
      CONCLUSIONS: Planar myocardial scintigraphy with Tc-99m-teboroxime can be 
      performed without major problems. In terms of clinical reliability the results 
      are comparable to those of TI-201 scans. On the other hand, taking into account 
      the poor image quality of Tc-99m-teboroxime scintigraphy, it is still impossible 
      to predict its future role in the radionuclide imaging of coronary artery 
      disease.
FAU - Bisi, G
AU  - Bisi G
AD  - Dipartimento di Fisiopatologia Clinica, Universita di Firenze.
FAU - Sciagra, R
AU  - Sciagra R
FAU - Santoro, G M
AU  - Santoro GM
FAU - Cerisano, G
AU  - Cerisano G
FAU - Vella, A
AU  - Vella A
FAU - Zerauschek, F
AU  - Zerauschek F
FAU - Fazzini, P F
AU  - Fazzini PF
LA  - ita
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Scintigrafia miocardica con Tc-99m-teboroxime: fattibilita e valutazione 
      dell'affidabilita diagnostica. Confronto con il tallio-201 e l'angiografia 
      coronarica.
PL  - Italy
TA  - G Ital Cardiol
JT  - Giornale italiano di cardiologia
JID - 1270331
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Oximes)
RN  - 0 (Thallium Radioisotopes)
RN  - UT0WHJ4951 (technetium Tc 99m teboroxime)
SB  - IM
MH  - Adult
MH  - Angina Pectoris/diagnostic imaging
MH  - *Coronary Angiography
MH  - Evaluation Studies as Topic
MH  - Feasibility Studies
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/diagnostic imaging
MH  - *Organotechnetium Compounds
MH  - *Oximes
MH  - Physical Exertion
MH  - Radionuclide Imaging
MH  - *Thallium Radioisotopes
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - G Ital Cardiol. 1992 Jul;22(7):795-805.