PMID- 14738321
OWN - NLM
STAT- MEDLINE
DCOM- 20040819
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 202
IP  - 1
DP  - 2004 Jan
TI  - Susceptibility patterns of enterococci causing infections.
PG  - 23-9
AB  - Enterococci are among the common organisms associated with hospital-acquired 
      infections. We examined in vitro activities of different antibiotics to 103 
      enterococcal isolates. Minimal inhibitory concentrations (MICs) of penicillin G, 
      ampicillin, gentamicin, ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, 
      trovafloxacin and gemifloxacin were determined by broth microdilution testing 
      method. Among the isolates 71 (69%) were identified as E. faecalis and 32 (31%) 
      as E. faecium. While over 75% of E. faecium isolates were resistant to penicillin 
      and ampicillin, approximately 25% of E. faecalis isolates were resistant to 
      penicillin and ampicillin. None of the E. faecalis and E. faecium isolates were 
      resistant to vancomycin. While 17 (52%) of E. faecium isolates exhibited 
      high-level gentamicin resistance (HLGR), high level streptomycin resistance 
      (HLSR) was detected in 24 (74%) of the isolates. In contrast, HLGR and HLSR rates 
      for E. faecalis were 14 (20%) and 22 (31%), respectively. Both HLGR and HLSR were 
      detected with higher frequency in ampicillin resistant isolates. Among 
      fluoroquinolones, gemifloxacin and trovafloxacin were the most potent antibiotics 
      tested. There was no increase in MIC90 values of the fluoroquinolones in 
      ampicillin resistant isolates in comparison with ampicillin susceptible isolates. 
      Our data suggest newer fluoroquinolones would be good alternative agents to use 
      especially for combination drug therapy where enterococci with ampicillin 
      resistance and HLAR are prevalent.
FAU - Oncu, Serkan
AU  - Oncu S
AD  - Department of Infectious Diseases and Clinical Microbiology, Adnan Menderes 
      University Faculty of Medicine, Aydin, Turkey. serkanoncu@hotmail.com
FAU - Punar, Metin
AU  - Punar M
FAU - Eraksoy, Haluk
AU  - Eraksoy H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Enterococcus faecalis/*drug effects
MH  - Enterococcus faecium/*drug effects
MH  - Gram-Positive Bacterial Infections/*drug therapy
MH  - Humans
EDAT- 2004/01/24 05:00
MHDA- 2004/08/20 05:00
CRDT- 2004/01/24 05:00
PHST- 2004/01/24 05:00 [pubmed]
PHST- 2004/08/20 05:00 [medline]
PHST- 2004/01/24 05:00 [entrez]
AID - 10.1620/tjem.202.23 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2004 Jan;202(1):23-9. doi: 10.1620/tjem.202.23.