PMID- 14738445
OWN - NLM
STAT- MEDLINE
DCOM- 20040310
LR  - 20190513
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 135
IP  - 2
DP  - 2004 Feb
TI  - Desferrioxamine modulates chemically induced T helper 2-mediated autoimmunity in 
      the rat.
PG  - 194-9
AB  - A rise in interleukin (IL) 4-dependent immunoglobulin E (IgE) is a hallmark of 
      the mercuric chloride (HgCl2)-induced Th2-mediated autoimmune syndrome in the 
      Brown Norway (BN) rat, and one of the mediators in allergic asthma in human. 
      Oxidative stress, a potential factor related to the pathogenesis of allergy and 
      asthma, has been shown to up-regulate IL-4 in mast cells and predispose to 
      degranulation in vitro. However, it remains unknown whether 
      oxidative/antioxidative imbalance plays a role in this Th2-driven model of 
      autoimmunity in the rat. Here we show that administration of the 
      non-sulphydryl-containing antioxidant desferrioxamine i.p. and s.c. to BN rats 
      reduces HgCl2-enhanced IL-4 gene expression and inhibits HgCl2-induced 
      Th2-mediated autoimmunity. Desferrioxamine treatment suppresses significantly IgE 
      production and lymphoproliferation, and reduces tissue injury in the form of 
      caecal vasculitis in the HgCl2-induced autoimmune syndrome. These results support 
      a role for oxidative stress in the pathogenesis of the HgCl2-induced 
      Th2-dominated autoimmune syndrome. This finding might have implications for 
      understanding the mechanisms involved in Th2 cell responses as seen in allergy 
      and asthma and thereby aid the development of new therapeutic strategies for 
      these diseases.
FAU - Wu, Z
AU  - Wu Z
AD  - Department of Cellular and Molecular Medicine, St George's Hospital Medical 
      School, London, UK. z.wu@sghms.ac.uk
FAU - Holwill, S D J
AU  - Holwill SD
FAU - Oliveira, D B G
AU  - Oliveira DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Iron Chelating Agents)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 53GH7MZT1R (Mercuric Chloride)
RN  - 82115-62-6 (Interferon-gamma)
RN  - J06Y7MXW4D (Deferoxamine)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology
MH  - Autoimmunity/*immunology
MH  - Deferoxamine/*pharmacology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Gene Expression/immunology
MH  - Immunoglobulin E/biosynthesis
MH  - Interferon-gamma/immunology
MH  - Interleukin-4/*immunology
MH  - Iron Chelating Agents/*pharmacology
MH  - Male
MH  - Mercuric Chloride/immunology
MH  - Oxidative Stress/immunology
MH  - Rats
MH  - Rats, Inbred BN
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - Spleen/immunology
MH  - Th2 Cells/*immunology
MH  - Vasculitis/immunology
PMC - PMC1808933
EDAT- 2004/01/24 05:00
MHDA- 2004/03/11 05:00
PMCR- 2005/02/01
CRDT- 2004/01/24 05:00
PHST- 2004/01/24 05:00 [pubmed]
PHST- 2004/03/11 05:00 [medline]
PHST- 2004/01/24 05:00 [entrez]
PHST- 2005/02/01 00:00 [pmc-release]
AID - 2372 [pii]
AID - 10.1111/j.1365-2249.2003.02372.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2004 Feb;135(2):194-9. doi: 10.1111/j.1365-2249.2003.02372.x.