PMID- 14741755
OWN - NLM
STAT- MEDLINE
DCOM- 20040503
LR  - 20190901
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 147
IP  - 1-2
DP  - 2003 Dec 30
TI  - Altered cocaine-induced behavioral sensitization in adult mice exposed to cocaine 
      in utero.
PG  - 97-105
AB  - Behavioral sensitization induced by psychostimulants is characterized by 
      increased locomotion and stereotypy and may reflect aspects of neuronal 
      adaptations underlying drug addiction in humans. To study the developmental 
      contributions to addictive behaviors, we measured behavioral responses in adult 
      offspring to a cocaine sensitization paradigm following prenatal cocaine 
      exposure. Pregnant Swiss-Webster (SW) mice were injected twice daily from 
      embryonic days 8 to 17 (E8-E17, inclusive) with cocaine (20 or 40 mg/kg/day; 
      COC20 and COC40, respectively), or saline vehicle (SAL and SPF40) subcutaneously 
      (s.c.). A nutritional control group of dams were 'pair-fed' with COC40 dams 
      (SPF40). P120 male offspring from each prenatal treatment group were assigned to 
      a behavioral sensitization group and injected with cocaine (15 mg/kg) or saline 
      intraperitoneally (i.p.) every other day for seven doses. Locomotor activity and 
      stereotypy were measured during habituation, cocaine initiation, and following a 
      cocaine challenge 21 days after the last initiation injection. As expected, 
      animals demonstrated significantly more locomotion and stereotypic behavior 
      following acute and recurrent injection of cocaine compared to saline-injected 
      animals. However, for each prenatal treatment group, cocaine-sensitized animals 
      showed unique temporal profiles for the increase in locomotor sensitization and 
      stereotypy over the course of the sensitization protocol. Two features that 
      distinguished the altered behavioral progression of prenatally cocaine-exposed 
      animals (COC40) from control (SAL) animals included blunted augmentation of 
      locomotion and enhanced patterns of stereotypic behavior. These findings provide 
      evidence that the behavioral activating effects of cocaine in adult animals are 
      altered following exposure to cocaine in utero.
FAU - Crozatier, Claire
AU  - Crozatier C
AD  - INSERM U513, Neurobiology and Psychiatry, Faculty of Medicine, 94010 Creteil, 
      France.
FAU - Guerriero, Rejean M
AU  - Guerriero RM
FAU - Mathieu, Flavie
AU  - Mathieu F
FAU - Giros, Bruno
AU  - Giros B
FAU - Nosten-Bertrand, Marika
AU  - Nosten-Bertrand M
FAU - Kosofsky, Barry E
AU  - Kosofsky BE
LA  - eng
GR  - DA 00354/DA/NIDA NIH HHS/United States
GR  - DA08648/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cocaine/adverse effects/*toxicity
MH  - Conditioning, Operant/drug effects
MH  - Female
MH  - Growth/drug effects
MH  - Habituation, Psychophysiologic/drug effects
MH  - Male
MH  - Mice
MH  - Motor Activity/*drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Stereotyped Behavior/drug effects
MH  - Substance Withdrawal Syndrome/psychology
EDAT- 2004/01/27 05:00
MHDA- 2004/05/05 05:00
CRDT- 2004/01/27 05:00
PHST- 2004/01/27 05:00 [pubmed]
PHST- 2004/05/05 05:00 [medline]
PHST- 2004/01/27 05:00 [entrez]
AID - S016538060300333X [pii]
AID - 10.1016/j.devbrainres.2003.10.006 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):97-105. doi: 
      10.1016/j.devbrainres.2003.10.006.