PMID- 14742644
OWN - NLM
STAT- MEDLINE
DCOM- 20040826
LR  - 20170214
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 83
IP  - 2
DP  - 2004 Feb
TI  - The molecular basis of salivary gland involvement in graft--vs.--host disease.
PG  - 98-103
AB  - During the past two decades, the involvement of salivary glands in graft vs. host 
      disease (GVHD) had been intensively researched and published. GVHD occurs in 
      40-70% of patients treated with bone marrow and peripheral blood stem cell 
      transplantation (PBSCT), and improved survival rates have led to a continuously 
      increasing number of GVHD patients suffering from induced salivary insult. 
      Limited studies suggest that a large percentage of GVHD patients is affected and 
      that the induced salivary dysfunction occurs rapidly following the 
      transplantation. It affects both major and minor salivary glands and reflects the 
      severity of the disease. Moreover, profound sialochemical alterations may be 
      diagnostic of GVHD. An additional reason for this vast research is that GVHD, as 
      an autoimmune-like disease, seemed to be an appropriate model for studying a much 
      more prevalent and well-known and well-studied autoimmune disease involving 
      salivary glands: Sjogren's syndrome. The purpose of the current review-which is, 
      to the best of our knowledge, the first of its kind-is to describe the 
      GVHD-related sialometric and sialochemical data published in the past two decades 
      for both major and minor salivary glands and to discuss the pathogenesis and 
      molecular basis of the disease.
FAU - Nagler, R M
AU  - Nagler RM
AD  - Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and 
      Salivary Clinic, Rambam Medical Center, and Faculty of Medicine, Technion-Israel 
      Institute of Technology, Haifa, Israel. nagler@tx.technion.ac.il
FAU - Nagler, A
AU  - Nagler A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
SB  - IM
MH  - Autoimmune Diseases/immunology
MH  - Bone Marrow Transplantation/immunology
MH  - Graft vs Host Disease/*immunology
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Molecular Biology
MH  - Saliva/chemistry
MH  - Salivary Gland Diseases/*immunology
MH  - Sjogren's Syndrome/immunology
RF  - 46
EDAT- 2004/01/27 05:00
MHDA- 2004/08/27 05:00
CRDT- 2004/01/27 05:00
PHST- 2004/01/27 05:00 [pubmed]
PHST- 2004/08/27 05:00 [medline]
PHST- 2004/01/27 05:00 [entrez]
AID - 10.1177/154405910408300203 [doi]
PST - ppublish
SO  - J Dent Res. 2004 Feb;83(2):98-103. doi: 10.1177/154405910408300203.