PMID- 14742724
OWN - NLM
STAT- MEDLINE
DCOM- 20041109
LR  - 20240413
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 556
IP  - Pt 1
DP  - 2004 Apr 1
TI  - Fuel selection during intense shivering in humans: EMG pattern reflects 
      carbohydrate oxidation.
PG  - 305-13
AB  - The thermogenic response of humans depends critically on the coordination of 
      muscle fibre recruitment and oxidative fuel metabolism. The primary goal of this 
      study was to determine whether the electromyographic (EMG) pattern of muscle 
      recruitment could provide metabolic information on oxidative fuel selection 
      during high-intensity shivering. EMG activity (of 8 large muscles) and fuel 
      metabolism were monitored simultaneously in non-acclimatized adult men during 
      high-intensity shivering. Even though acute cold exposure elicited similar 
      changes in metabolic rate among subjects, lipid and carbohydrate use was very 
      different. Depending on the subject, the cold-induced increase in carbohydrate 
      (CHO) oxidation ranged between 2- and 8-fold, with CHO accounting for 33-78% of 
      total heat production, and lipids for 14-60%. This high variability in fuel 
      selection was primarily explained by differences in 'burst shivering' rate, 
      indicating that the recruitment of type II fibres plays a key role in 
      orchestrating fuel selection. This study is the first to show that the pattern of 
      muscle recruitment can provide quantitative information on energy metabolism. 
      Future work should focus on the study of shivering bursts that may provide 
      essential clues on what limits human survival in the cold.
FAU - Haman, Francois
AU  - Haman F
AD  - Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada 
      K1N 6N5.
FAU - Legault, Stephane R
AU  - Legault SR
FAU - Weber, Jean-Michel
AU  - Weber JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040123
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Adult
MH  - Body Temperature
MH  - *Carbohydrate Metabolism
MH  - Electromyography
MH  - Energy Metabolism/physiology
MH  - Esophagus/physiology
MH  - Humans
MH  - *Lipid Metabolism
MH  - Male
MH  - Muscle, Skeletal/*physiology
MH  - Oxidation-Reduction
MH  - Shivering/*physiology
MH  - Skin Temperature
MH  - Thermogenesis/*physiology
PMC - PMC1664890
EDAT- 2004/01/27 05:00
MHDA- 2004/11/13 09:00
PMCR- 2005/04/01
CRDT- 2004/01/27 05:00
PHST- 2004/01/27 05:00 [pubmed]
PHST- 2004/11/13 09:00 [medline]
PHST- 2004/01/27 05:00 [entrez]
PHST- 2005/04/01 00:00 [pmc-release]
AID - jphysiol.2003.055152 [pii]
AID - 10.1113/jphysiol.2003.055152 [doi]
PST - ppublish
SO  - J Physiol. 2004 Apr 1;556(Pt 1):305-13. doi: 10.1113/jphysiol.2003.055152. Epub 
      2004 Jan 23.