PMID- 14743629
OWN - NLM
STAT- MEDLINE
DCOM- 20040722
LR  - 20061115
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 38
IP  - 4
DP  - 2003 Aug
TI  - [Expression of toll-like receptor mRNA in epithelial cell of nasal mucosa].
PG  - 243-6
AB  - OBJECTIVE: To understand the expression of Toll-like receptor-2 (TLR-2) and 
      Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to 
      investigate the role of Toll-like receptors in the innate immunity of nasal 
      mucosa. METHODS: Specimens from 30 patients with chronic sinusitis and 21 healthy 
      adults were examined by in situ hybridization for TLR-2 and TLR-4 mRNA. RESULTS: 
      All 30, samples of chronic sinusitis showed a stranger expression of TLR-2 and 
      TLR-4 than in controls (t = 8.605, P < 0.0005, t = 9.050, P < 0.0005). 
      CONCLUSION: It is suggested that epithelial in nasal mucosa were not just a 
      physical barrier, which could represent a novel defense mechanism of the host 
      during bacterial infections through Toll-like receptors.
FAU - Wang, Cheng-shuo
AU  - Wang CS
AD  - Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union 
      Hospital of Jilin University, Changchun 130031, China.
FAU - Dong, Zhen
AU  - Dong Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (TLR2 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chronic Disease
MH  - Epithelial Cells/*metabolism
MH  - Female
MH  - Humans
MH  - In Situ Hybridization
MH  - Male
MH  - Membrane Glycoproteins/*biosynthesis/genetics/immunology
MH  - Middle Aged
MH  - Nasal Mucosa/*metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Receptors, Cell Surface/*biosynthesis/genetics/immunology
MH  - Signal Transduction
MH  - Sinusitis/*metabolism
MH  - Toll-Like Receptor 2
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
EDAT- 2004/01/28 05:00
MHDA- 2004/07/23 05:00
CRDT- 2004/01/28 05:00
PHST- 2004/01/28 05:00 [pubmed]
PHST- 2004/07/23 05:00 [medline]
PHST- 2004/01/28 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):243-6.