PMID- 14744554
OWN - NLM
STAT- MEDLINE
DCOM- 20040305
LR  - 20190922
IS  - 0001-706X (Print)
IS  - 0001-706X (Linking)
VI  - 89
IP  - 3
DP  - 2004 Feb
TI  - A potential role of interleukin 18 in severe falciparum malaria.
PG  - 279-84
AB  - Interleukin-18 (IL-18) is a potent proinflammatory cytokine that induces 
      interferon-gamma (IFN-gamma) production from Th1 cells, NK cells and activated 
      macrophages, particularly in the presence of IL-12. However, it is also shown 
      that without help from IL-12, IL-18 is capable of inducing IL-4 and IL-13 
      production in T cells, NK cells, mast cells and basophils, and that 
      administration of IL-18 in conjunction with an allergen increases serum IgE 
      levels. In order to clarify the role of IL-18 in disease severity of falciparum 
      malaria, we have examined serum levels of IL-18, IFN-gamma, and IgE for 96 
      patients with falciparum malaria [Trans. R. Soc. Trop. Med. Hyg. 97, 236-241]. 
      Results suggested that IL-18 plays a key role in inducing severe malaria through 
      a pathway of elevating IFN-gamma, rather than its IgE inducing activity. Based on 
      these results, the role of IL-18 in severe falciparum malaria will be discussed 
      in this review.
FAU - Kojima, Somei
AU  - Kojima S
AD  - Department of Parasitology, Institute of Medical Science, The University of 
      Tokyo, Tokyo, Japan. fnskj@diamond.manhidol.ac.th
FAU - Nagamine, Yukiko
AU  - Nagamine Y
FAU - Hayano, Masashi
AU  - Hayano M
FAU - Looareesuwan, Sornchai
AU  - Looareesuwan S
FAU - Nakanishi, Kenji
AU  - Nakanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Interleukin-18)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/*blood
MH  - Interleukin-18/blood/*physiology
MH  - Malaria, Falciparum/*blood/classification/pathology
MH  - Middle Aged
MH  - Plasmodium falciparum/*pathogenicity
MH  - Severity of Illness Index
RF  - 38
EDAT- 2004/01/28 05:00
MHDA- 2004/03/06 05:00
CRDT- 2004/01/28 05:00
PHST- 2004/01/28 05:00 [pubmed]
PHST- 2004/03/06 05:00 [medline]
PHST- 2004/01/28 05:00 [entrez]
AID - S0001706X03002754 [pii]
AID - 10.1016/j.actatropica.2003.10.005 [doi]
PST - ppublish
SO  - Acta Trop. 2004 Feb;89(3):279-84. doi: 10.1016/j.actatropica.2003.10.005.