PMID- 14745144
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20191210
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 68
IP  - 2
DP  - 2004 Feb
TI  - Plasma concentrations of monocyte chemoattractant protein 1 (MCP-1) and neopterin 
      in the coronary circulation of patients with coronary artery disease.
PG  - 114-20
AB  - BACKGROUND: The dynamics of MCP-1 and neopterin and the relation between their 
      concentrations in coronary circulation and the severity of coronary 
      atherosclerosis were evaluated in patients with stable coronary artery disease 
      (CAD). METHODS AND RESULTS: Blood samples were obtained from the aortic root (Ao) 
      and coronary sinus (CS) of 78 patients who underwent coronary angiography. Plasma 
      MCP-1 and neopterin concentrations were measured using an enzyme-linked 
      immunosorbent assay method and the CS-Ao differences were calculated. The 
      severity of coronary heart disease (CHD) was evaluated in 52 patients who had no 
      history of coronary angioplasty, using 3 coronary scoring systems: the clinical 
      1- to 3-vessel disease score, the American Heart Association extension score 
      (1-15 segments), and the Gensini score. The plasma MCP-1 and neopterin 
      concentrations increased significantly with age. The CS-Ao differences for 
      neopterin showed weak, but significant, positive correlation with the Gensini 
      score (r=0.347, p=0.013). There were no correlations among the MCP-1 
      concentrations in the Ao or CS, or in the CS-Ao difference, with the severity of 
      CHD. CONCLUSIONS: The results indicate that neopterin is a useful marker of the 
      severity of coronary atherosclerosis in patients with stable CAD, acting as an 
      index of the activity of monocytes/macrophages.
FAU - Tanaka, Takayuki
AU  - Tanaka T
AD  - Division of Cardiology, Niigata University Graduate School of Medical & Dental 
      Sciences., Japan.
FAU - Nakamura, Yuichi
AU  - Nakamura Y
FAU - Nasuno, Akimitsu
AU  - Nasuno A
FAU - Mezaki, Tohru
AU  - Mezaki T
FAU - Higuchi, Koutarou
AU  - Higuchi K
FAU - Fukunaga, Hiroshi
AU  - Fukunaga H
FAU - Tsuchida, Keiichi
AU  - Tsuchida K
FAU - Ozaki, Kazuyuki
AU  - Ozaki K
FAU - Hori, Tomoyuki
AU  - Hori T
FAU - Matsubara, Taku
AU  - Matsubara T
FAU - Aizawa, Yoshifusa
AU  - Aizawa Y
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 670-65-5 (Neopterin)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Coronary Artery Disease/*blood
MH  - Coronary Circulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/metabolism
MH  - Neopterin/*blood
MH  - *Severity of Illness Index
EDAT- 2004/01/28 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/01/28 05:00
PHST- 2004/01/28 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/01/28 05:00 [entrez]
AID - 10.1253/circj.68.114 [doi]
PST - ppublish
SO  - Circ J. 2004 Feb;68(2):114-20. doi: 10.1253/circj.68.114.