PMID- 14745711
OWN - NLM
STAT- MEDLINE
DCOM- 20040405
LR  - 20220330
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 189
IP  - 3
DP  - 2004 Feb 1
TI  - Influence of human leukocyte antigen class II alleles on susceptibility to 
      Entamoeba histolytica infection in Bangladeshi children.
PG  - 520-6
AB  - BACKGROUND: The association of antibody responses with both innate and acquired 
      immunity to amebiasis indicate that CD4+ T cells play a role in protection 
      against Entamoeba histolytica infection. To test this hypothesis, we compared the 
      genotype frequencies of human leukocyte antigen (HLA) class II alleles in a 
      cohort of Bangladeshi children intensively monitored for E. histolytica infection 
      for a 3-year period. METHODS: Using logistic regression, we calculated the odds 
      of disease by genotype and by haplotype. RESULTS: The DQB1*0601 heterozygous and 
      homozygous genotypes were found in 55% of E. histolytica-negative children but in 
      only 34% of E. histolytica-positive children (overall odds ratio, 2.39; 95% 
      confidence interval [CI], 1.26-4.54). Children who were heterozygous for the 
      DQB1*0601/DRB1*1501 haplotype were 10.1 times (95% CI, 2.02-50.6) more likely to 
      be both E. histolytica negative and serum anti-lectin immunoglobulin G negative 
      at baseline. Other DQB1 and DRB1 alleles (DQB1*0202, DQB1*0301, and DRB1*0701) 
      were not associated with any of the clinical outcomes related to amebiasis. 
      CONCLUSION: A potential protective association was observed with the HLA class II 
      allele DQB1*0601 and the heterozygous haplotype DQB1*0601/DRB1*1501. This 
      association may explain why amebiasis does not occur in some children who are 
      exposed to the parasite and implicates HLA class II-restricted immune responses 
      in protection against E. histolytica infection.
FAU - Duggal, Priya
AU  - Duggal P
AD  - Department of Epidemiology, Johns Hopkins University Bloomberg School of Public 
      Health, Baltimore, Maryland, USA.
FAU - Haque, Rashidul
AU  - Haque R
FAU - Roy, Shantanu
AU  - Roy S
FAU - Mondal, Dinesh
AU  - Mondal D
FAU - Sack, R Bradley
AU  - Sack RB
FAU - Farr, Barry M
AU  - Farr BM
FAU - Beaty, Terri H
AU  - Beaty TH
FAU - Petri, William A Jr
AU  - Petri WA Jr
LA  - eng
GR  - R01 AI043596/AI/NIAID NIH HHS/United States
GR  - AI-43596/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040120
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - *Alleles
MH  - Animals
MH  - Antibodies, Protozoan/blood
MH  - Bangladesh
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Entamoeba histolytica/immunology
MH  - Entamoebiasis/blood/*genetics/immunology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Logistic Models
MH  - Male
MH  - Prospective Studies
MH  - Urban Population
EDAT- 2004/01/28 05:00
MHDA- 2004/04/06 05:00
CRDT- 2004/01/28 05:00
PHST- 2003/05/27 00:00 [received]
PHST- 2003/08/20 00:00 [accepted]
PHST- 2004/01/28 05:00 [pubmed]
PHST- 2004/04/06 05:00 [medline]
PHST- 2004/01/28 05:00 [entrez]
AID - JID31174 [pii]
AID - 10.1086/381272 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Feb 1;189(3):520-6. doi: 10.1086/381272. Epub 2004 Jan 20.