PMID- 14746895
OWN - NLM
STAT- MEDLINE
DCOM- 20040329
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 356
IP  - 1
DP  - 2004 Feb 6
TI  - The alpha 1D-adrenergic receptor modulates cardiovascular and drinking responses 
      to central salt loading in mice.
PG  - 33-6
AB  - To characterize the involvement of specific alpha(1)-adrenergic receptor 
      (alpha(1)-AR) subtypes in hypertension, parameters related to central salt- or 
      angiotensin II (ANG II)-induced hypertension were investigated in 
      alpha(1D)-AR-deficient mice (knockout). Baseline daily water intake and food 
      intake were larger in alpha(1D)(-/-) mice than in alpha(1D)(+/+) mice. 
      Intracerebroventricular (i.c.v.) administration of NaCl (0.67 M NaCl, 1 microl) 
      elicited smaller increases in mean arterial blood pressure (MABP), heart rate, 
      and water intake in alpha(1D)(-/-) mice than it did in alpha(1D)(+/+) mice. 
      I.c.v. administration of ANG II (10 pmol) resulted in increases in MABP and water 
      intake that were similar in alpha(1D)(-/-) mice and alpha(1D)(+/+) mice. These 
      results suggest that alpha(1D)-AR is, at least in part, involved in central 
      salt-induced but not ANG II-induced hypertension and water intake.
FAU - Chu, Chun-Ping
AU  - Chu CP
AD  - Department of Physiology, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, 
      Miyazaki-gun, Miyazaki 889-1692, Japan.
FAU - Kunitake, Takato
AU  - Kunitake T
FAU - Kato, Kazuo
AU  - Kato K
FAU - Watanabe, Shoichi
AU  - Watanabe S
FAU - Qiu, De-Lai
AU  - Qiu DL
FAU - Tanoue, Akito
AU  - Tanoue A
FAU - Kannan, Hiroshi
AU  - Kannan H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Adra1d protein, mouse)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects/*physiology
MH  - Cardiovascular System/drug effects/metabolism
MH  - Drinking Behavior/drug effects/*physiology
MH  - Heart Rate/drug effects/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, Adrenergic, alpha-1/*physiology
MH  - Sodium Chloride, Dietary/*pharmacology
EDAT- 2004/01/30 05:00
MHDA- 2004/03/30 05:00
CRDT- 2004/01/30 05:00
PHST- 2004/01/30 05:00 [pubmed]
PHST- 2004/03/30 05:00 [medline]
PHST- 2004/01/30 05:00 [entrez]
AID - S0304394003013387 [pii]
AID - 10.1016/j.neulet.2003.11.014 [doi]
PST - ppublish
SO  - Neurosci Lett. 2004 Feb 6;356(1):33-6. doi: 10.1016/j.neulet.2003.11.014.