PMID- 14749004
OWN - NLM
STAT- MEDLINE
DCOM- 20040506
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 41
IP  - 6
DP  - 2003 Jun
TI  - [Role of free radicals in brain edema induced by endotoxin in infant rats and the 
      therapeutic effect of dexamethasone and IVIG].
PG  - 448-52
AB  - OBJECTIVE: Glucocorticoid is considered as an effective drug for prevention and 
      treatment of brain edema and reducing the blood-brain barrier (BBB) permeability. 
      Intravenous immunoglobulin (IVIG) is frequently used to treat neurological 
      diseases with immune abnormality, its function and potential mechanism on brain 
      edema have not been reported. In this study, the roles of the total hydrosulfide 
      group (TSH), non-protein hydrosulfide group (NPSH) and malondialdehyde (MDA) in 
      etiology of the endotoxin brain edema in infant rats and the interfering effects 
      of dexamethasone (DEX) and IVIG were investigated. METHODS: In 35 infant rats, 10 
      mg/kg lipopolysaccharide (LPS) was intraperitoneally injected. The same volume of 
      normal saline was injected to 24 control rats. Ten mg/kg DEX and 400 mg/kg IVIG 
      were intravenously injected respectively to 36 and 24 infant rats instantly 
      following LPS injection. The TSH, NPSH and MDA concentrations and the brain Evans 
      blue contents were detected at different time in the brain tissue. The brain 
      water content was measured by drying method. RESULTS: The brain water, EB and MDA 
      contents after endotoxin injection were significantly higher than those of 
      control group, while the brain TSH, NPSH content were significantly lower than 
      those of control group (P < 0.05 or P < 0.01); After treatment with DEX or IVIG, 
      the brain EB, MDA and water content significantly decreased with the peak at 6 h 
      (P < 0.05 or P < 0.01), TSH and NPSH significantly increased compared with LPS 
      group. However, the NPSH content in IVIG treatment group did not change 
      significantly (P > 0.05). CONCLUSION: Free radicals play a role in the brain 
      edema induced by LPS in infant rats. The primary results suggested that DEX and 
      IVIG have therapeutic effect for the endotoxin-induced brain edema by affecting 
      the free radicals.
FAU - Li, Mei
AU  - Li M
AD  - Department of Neurology, Children's Hospital, Chongqing Medical University, 
      Chongqing 400014, China.
FAU - Cai, Fang-cheng
AU  - Cai FC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
RN  - 0 (Endotoxins)
RN  - 0 (Free Radicals)
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Sulfides)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/drug effects/metabolism
MH  - Brain Edema/chemically induced/*drug therapy/metabolism
MH  - Dexamethasone/*therapeutic use
MH  - Endotoxins/*toxicity
MH  - Free Radicals/*analysis
MH  - Glucocorticoids/therapeutic use
MH  - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use
MH  - Malondialdehyde/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Sulfides/analysis
EDAT- 2004/01/30 05:00
MHDA- 2004/05/07 05:00
CRDT- 2004/01/30 05:00
PHST- 2004/01/30 05:00 [pubmed]
PHST- 2004/05/07 05:00 [medline]
PHST- 2004/01/30 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2003 Jun;41(6):448-52.