PMID- 14750650
OWN - NLM
STAT- MEDLINE
DCOM- 20040312
LR  - 20141120
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 13
IP  - 8
DP  - 2003
TI  - Unilateral inner ear damage results in lasting changes in hippocampal CA1 field 
      potentials in vitro.
PG  - 873-8
AB  - We investigated the effects of a surgical lesion of one vestibular inner ear 
      (unilateral vestibular damage [UVD]) on the field potential responses of CA1 
      neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 
      months post-UVD, and the field responses of CA1 neurons to electrical stimulation 
      of the Schaffer collateral commissural pathway were analyzed. Compared with 
      slices from sham and naive control animals, slices from UVD animals at 5-6 months 
      post-UVD exhibited decreases in the population spike amplitude, the somal field 
      excitatory postsynaptic potential (sfEPSP) slope, and the field EPSP (fEPSP) 
      slope. For the population spike amplitude and fEPSP slope, this effect was 
      observed in both CA1 ipsilateral and contralateral to the UVD. On both the 
      ipsilateral and contralateral sides, paired-pulse testing showed increases in 
      paired-pulse inhibition at the shortest interstimulus intervals (ISIs), with 
      increases in paired-pulse facilitation at longer ISIs. This study provides the 
      first evidence that peripheral vestibular damage can produce long-term changes in 
      hippocampal electrophysiological activity in vitro.
FAU - Zheng, Yiwen
AU  - Zheng Y
AD  - Department of Pharmacology and Toxicology, School of Medical Sciences, University 
      of Otago, Dunedin, New Zealand.
FAU - Kerr, D Steven
AU  - Kerr DS
FAU - Darlington, Cynthia L
AU  - Darlington CL
FAU - Smith, Paul F
AU  - Smith PF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Action Potentials/physiology
MH  - Afferent Pathways/injuries/*physiopathology
MH  - Animals
MH  - Axons/physiology
MH  - Denervation
MH  - Electric Stimulation
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Hippocampus/*physiopathology
MH  - In Vitro Techniques
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Synaptic Transmission/physiology
MH  - Vestibular Diseases/*physiopathology
MH  - Vestibule, Labyrinth/injuries/*physiopathology
EDAT- 2004/01/31 05:00
MHDA- 2004/03/16 05:00
CRDT- 2004/01/31 05:00
PHST- 2004/01/31 05:00 [pubmed]
PHST- 2004/03/16 05:00 [medline]
PHST- 2004/01/31 05:00 [entrez]
AID - 10.1002/hipo.10174 [doi]
PST - ppublish
SO  - Hippocampus. 2003;13(8):873-8. doi: 10.1002/hipo.10174.