PMID- 14751419
OWN - NLM
STAT- MEDLINE
DCOM- 20040528
LR  - 20190911
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 28
IP  - 2
DP  - 2004 Mar
TI  - Anxiogenic-like activity of 3,4-methylenedioxy-methamphetamine ("Ecstasy") in the 
      social interaction test is accompanied by an increase of c-fos expression in mice 
      amygdala.
PG  - 249-54
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a synthetic amphetamine popularly 
      known as "Ecstasy." Animal studies examining acute effects of MDMA on anxiety are 
      unclear because although an anxiolytic-like action of MDMA in different animal 
      models of anxiety has been described, there is also substantial evidence 
      supporting an anxiogenic-like effect of this drug. To date, several studies have 
      examined c-fos expression following MDMA administration in rats. However, there 
      is no information about the MDMA-induced c-fos expression in mice previously 
      tested in an animal model of anxiety. In this study, male mice were injected with 
      MDMA (1, 8 and 15 mg/kg ip) and assessed for changes on anxiety and for the 
      expression of the immediate early gene c-fos in the amygdala (central, 
      basolateral and basomedial). Anxiety was evaluated by the "social interaction 
      test." Ten behavioral categories were recorded: body care, digging, nonsocial 
      exploration, exploration from a distance, social investigation, threat, attack, 
      avoidance/flee, defense/submission and immobility. As compared with the control 
      group, mice treated with MDMA (all doses) showed a decrease in mean duration and 
      total time spent in social investigation behaviors, whereas avoidance/flee 
      behaviors were significantly increased after treatment with this compound (8 and 
      15 mg/kg). Likewise, a significant increase in c-fos expression was found in the 
      basolateral (all doses) and central (15 mg/kg) amygdala after MDMA 
      administration. Overall, these findings indicate that MDMA exhibits an 
      anxiogenic-like profile in the social interaction test in mice, and that central 
      and basolateral amygdala might be involved in these anxiogenic-like effects of 
      the drug.
FAU - Navarro, Jose Francisco
AU  - Navarro JF
AD  - Department of Psychobiology, Faculty of Psychology, University of Malaga, Campus 
      de Teatinos, s/n 29071 Malaga, Spain. navahuma@uma.es
FAU - Rivera, Alicia
AU  - Rivera A
FAU - Maldonado, Enrique
AU  - Maldonado E
FAU - Cavas, Maria
AU  - Cavas M
FAU - de la Calle, Adelaida
AU  - de la Calle A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Hallucinogens)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amygdala/*drug effects/metabolism
MH  - Animals
MH  - Behavior, Animal
MH  - Cell Count/methods
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression/drug effects
MH  - Hallucinogens/*pharmacology
MH  - Immunohistochemistry/methods
MH  - *Interpersonal Relations
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Statistics, Nonparametric
EDAT- 2004/01/31 05:00
MHDA- 2004/05/29 05:00
CRDT- 2004/01/31 05:00
PHST- 2004/01/31 05:00 [pubmed]
PHST- 2004/05/29 05:00 [medline]
PHST- 2004/01/31 05:00 [entrez]
AID - S0278584603002513 [pii]
AID - 10.1016/j.pnpbp.2003.10.016 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):249-54. doi: 
      10.1016/j.pnpbp.2003.10.016.