PMID- 14752588
OWN - NLM
STAT- MEDLINE
DCOM- 20041122
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 173
IP  - 3-4
DP  - 2004 May
TI  - Decreased pain tolerance and mood in recreational users of MDMA.
PG  - 446-51
AB  - RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) is known to affect brain 
      serotonin (5-HT) neurons in experimental animals. However, its effects on humans 
      are more difficult to infer. Serotonin is implicated in the body's ability to 
      modulate the effects of pain and to regulate mood. OBJECTIVE: The aim of this 
      research is to test nociceptive responses and mood in MDMA users as an index of 
      central 5-HT function. METHOD: Measurements of pain tolerance were obtained using 
      the cold-pressor test for 15 polydrug users who regularly use MDMA, 3-4 days 
      after the most recent usage, and ten matched polydrug users who do not use MDMA. 
      A rating on mood was obtained for each participant using the Nowlis Mood 
      Adjective checklist. RESULTS: Measurements of pain tolerance and mood were 
      significantly lower in the MDMA group. A positive correlation between mood and 
      pain tolerance was found in the MDMA group, whereas no correlation was found 
      between these variables in the non-MDMA group CONCLUSION: This study found an 
      association between pain tolerance and MDMA usage and confirmed the association 
      between MDMA and depressed mood. The current results suggest that MDMA, at least 
      in the short term, may cause serotonin-mediated alterations in pain sensitivity.
FAU - O'Regan, Margaret Claire
AU  - O'Regan MC
AD  - Department of Psychology, University of Westminster, 309 Regent Street, London, 
      W1B 2UW, UK.
FAU - Clow, Angela
AU  - Clow A
LA  - eng
PT  - Journal Article
DEP - 20040130
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Affect/*drug effects
MH  - Central Nervous System Stimulants/*adverse effects
MH  - Female
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Pain Threshold/*drug effects
EDAT- 2004/01/31 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/01/31 05:00
PHST- 2003/08/21 00:00 [received]
PHST- 2003/11/28 00:00 [accepted]
PHST- 2004/01/31 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/01/31 05:00 [entrez]
AID - 10.1007/s00213-003-1748-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2004 May;173(3-4):446-51. doi: 
      10.1007/s00213-003-1748-8. Epub 2004 Jan 30.