PMID- 14753482
OWN - NLM
STAT- MEDLINE
DCOM- 20040309
LR  - 20190917
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 86
DP  - 2003
TI  - The International Surgical Trial in Intracerebral Haemorrhage (ISTICH).
PG  - 441-3
AB  - At the XIth International Brain Oedema Symposium we reported that 208 patients 
      had been randomized in this trial from 65 centres. At the time of submission of 
      this manuscript we have randomized 985 patients from 107 centres including Japan. 
      The trial will continue randomising patients until the end of February 2003. The 
      objective is to determine whether "Early Surgical Intervention" or "Initial 
      Conservative Treatment" is the best option in patients with spontaneous 
      supratentorial Intracerebral haemorrhage (ICH). Patients with trauma, tumours, 
      aneurysms and angiographically proven arteriovenous malformations are excluded. 
      Ascertainment logs from the various centres have revealed substantial variation 
      in the rate of operation for ICH from 2% in Hungary to 90% in Lithuania. The 
      results will remain blinded until all 6 month follow-up information has been 
      obtained. It is anticipated that these results will therefore be known towards 
      the end of 2003. The pooled results have shown that patients with larger 
      Haematomas and depressed consciousness are more likely to end up with a worse 
      outcome.
FAU - Mendelow, A D
AU  - Mendelow AD
AD  - Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, 
      England.
CN  - Investigators and the Steering Committee
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
SB  - IM
MH  - Cerebral Hemorrhage/physiopathology/*surgery
MH  - Female
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Internationality
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Single-Blind Method
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2004/02/03 05:00
MHDA- 2004/03/10 05:00
CRDT- 2004/02/03 05:00
PHST- 2004/02/03 05:00 [pubmed]
PHST- 2004/03/10 05:00 [medline]
PHST- 2004/02/03 05:00 [entrez]
AID - 10.1007/978-3-7091-0651-8_90 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2003;86:441-3. doi: 10.1007/978-3-7091-0651-8_90.