PMID- 14755482
OWN - NLM
STAT- MEDLINE
DCOM- 20040302
LR  - 20220317
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 29
IP  - 2
DP  - 2004 Feb
TI  - Matrix metalloproteinases and skeletal muscle: a brief review.
PG  - 191-7
AB  - Matrix metalloproteinases (MMPs) are a family of zinc- dependent proteolytic 
      enzymes that function mainly in the extracellular matrix, where they contribute 
      to the development, functioning, and pathology of a wide range of tissues. This 
      mini-review describes the MMPs and tissue inhibitors of MMPs (TIMPs) in skeletal 
      muscle, and considers their involvement in muscle development, ischemia, 
      myonecrosis, angiogenesis, denervation, exercise-induced injuries, disuse 
      atrophy, muscle repair and regeneration, and inflammatory myopathies and 
      dystrophies. Despite the very limited information currently available on MMPs and 
      their inhibitors in skeletal muscle, it is becoming increasingly clear that they 
      have important physiological functions in maintenance of the integrity and 
      homeostasis of muscle fibers and of the extracellular matrix. Understanding the 
      roles of MMPs and TIMPs may lead to the development of new drug-related 
      treatments for various muscle disorders based on suppression or upregulation of 
      their expression.
FAU - Carmeli, Eli
AU  - Carmeli E
AD  - Department of Physical Therapy, Sackler Faculty of Medicine, Stanley Steyer 
      School of Health Professions, Tel Aviv University, Ramat Aviv 69978, Israel. 
      elie@post.tau.ac.il
FAU - Moas, Miri
AU  - Moas M
FAU - Reznick, Abraham Z
AU  - Reznick AZ
FAU - Coleman, Raymond
AU  - Coleman R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Enzyme Inhibitors/pharmacology/therapeutic use
MH  - Humans
MH  - Matrix Metalloproteinase Inhibitors
MH  - Matrix Metalloproteinases/*metabolism
MH  - Muscle, Skeletal/drug effects/*enzymology/pathology
MH  - Muscular Diseases/drug therapy/enzymology/pathology
RF  - 43
EDAT- 2004/02/03 05:00
MHDA- 2004/03/03 05:00
CRDT- 2004/02/03 05:00
PHST- 2004/02/03 05:00 [pubmed]
PHST- 2004/03/03 05:00 [medline]
PHST- 2004/02/03 05:00 [entrez]
AID - 10.1002/mus.10529 [doi]
PST - ppublish
SO  - Muscle Nerve. 2004 Feb;29(2):191-7. doi: 10.1002/mus.10529.