PMID- 14757036 OWN - NLM STAT- MEDLINE DCOM- 20040413 LR - 20081121 IS - 0167-7799 (Print) IS - 0167-7799 (Linking) VI - 22 IP - 2 DP - 2004 Feb TI - Tracking the 'general': tagging skin-derived dendritic cells. PG - 58-9 AB - Dendritic cells (DCs) are the sentinels of the immune system; their migration, maturation and mobilization are fundamental to immunity and tolerance. The recent tracking of DCs from the skin to lymph node (LN) and their enumeration using a Cre/loxP system demonstrate the recruitment of a higher than expected number of DCs to the draining LN after cutaneous administration of DNA-coated gold particles. The longevity of the migrated DCs was also longer than previously reported. FAU - Raju, Raghavan AU - Raju R AD - Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 4N252, 10 Center Drive, Bethesda, MD 20892, USA. RajuR@ninds.nih.gov LA - eng PT - Journal Article PL - England TA - Trends Biotechnol JT - Trends in biotechnology JID - 8310903 SB - IM MH - Cell Movement/*physiology MH - Dendritic Cells/*cytology/*physiology MH - Lymph Nodes/*physiology MH - *Skin Physiological Phenomena MH - Spectrometry, Fluorescence/methods MH - Staining and Labeling/methods EDAT- 2004/02/06 05:00 MHDA- 2004/04/14 05:00 CRDT- 2004/02/06 05:00 PHST- 2004/02/06 05:00 [pubmed] PHST- 2004/04/14 05:00 [medline] PHST- 2004/02/06 05:00 [entrez] AID - S0167-7799(03)00312-3 [pii] AID - 10.1016/j.tibtech.2003.11.005 [doi] PST - ppublish SO - Trends Biotechnol. 2004 Feb;22(2):58-9. doi: 10.1016/j.tibtech.2003.11.005.