PMID- 14757261
OWN - NLM
STAT- MEDLINE
DCOM- 20040901
LR  - 20190917
IS  - 0378-3782 (Print)
IS  - 0378-3782 (Linking)
VI  - 76
IP  - 2
DP  - 2004 Feb
TI  - Diastolic left ventricular function in preterm infants with a patent ductus 
      arteriosus: a serial Doppler echocardiography study.
PG  - 91-100
AB  - In very low birth weight neonates, a left-to-right shunt via persistent ductus 
      arteriosus (PDA) may interact with diastolic left ventricular function, but 
      specific changes of Doppler parameters have yet to be reported. In a serial 
      transmitral Doppler study, we investigated the impact of a PDA on diastolic 
      function parameters. Twenty-two patients with and without PDA were examined on 
      day 3.8+/-1 and day 14+/-2 after birth. By the first examination, 13 out of 22 
      patients had a PDA; by the second examination, the number was still 8 out of 22. 
      Peak early and atrial flow velocities (44.8+/-15 and 50.1+/-13 cm/s, 
      respectively) were higher (p<0.05) for neonates with PDA compared to those with 
      closed duct (30.9+/-6 and 34.2 cm/s, respectively). Isovolumic relaxation time 
      (IVRT) was shorter in neonates with PDA (45+/-7 ms, N=21) compared to those with 
      a closed duct (55.3+/-5 ms, N=23) (p<0.01). IVRT correlated inversely with 
      cardiac index (R=-0.79, p<0.01). All observed changes reversed to the normal 
      range after closure of the PDA. When premature infants with a PDA experience a 
      preload challenge, early and atrial peak velocities increase and IVRT shortens 
      significantly. This coincidence of elevated transvalvular pressure differences 
      and decreased IVRT in neonates with immature diastolic function can best be 
      explained as a result of left atrial pressure elevation. Consequently, pulmonary 
      venous pressure must be elevated, with its inherent effect on pulmonary capillary 
      physiology. Thus, the monitoring of left ventricular diastolic function adds 
      significant information to the care of preterm infants with a PDA.
FAU - Schmitz, Lothar
AU  - Schmitz L
AD  - Department of Pediatric Cardiology, Charite Medical Center, Humboldt-University, 
      Augustenburger Platz 1, D-13353 Berlin, Germany. lothar.schmitz@berlin.de
FAU - Stiller, Brigitte
AU  - Stiller B
FAU - Koch, Heike
AU  - Koch H
FAU - Koehne, Petra
AU  - Koehne P
FAU - Lange, Peter
AU  - Lange P
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - Blood Gas Analysis
MH  - *Diastole
MH  - Ductus Arteriosus, Patent/blood/*diagnostic imaging/physiopathology
MH  - Echocardiography, Doppler/*methods
MH  - Follow-Up Studies
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/blood/*diagnostic imaging/physiopathology
MH  - Infant, Very Low Birth Weight
MH  - *Ventricular Function, Left
EDAT- 2004/02/06 05:00
MHDA- 2004/09/02 05:00
CRDT- 2004/02/06 05:00
PHST- 2004/02/06 05:00 [pubmed]
PHST- 2004/09/02 05:00 [medline]
PHST- 2004/02/06 05:00 [entrez]
AID - S0378378203001968 [pii]
AID - 10.1016/j.earlhumdev.2003.11.002 [doi]
PST - ppublish
SO  - Early Hum Dev. 2004 Feb;76(2):91-100. doi: 10.1016/j.earlhumdev.2003.11.002.