PMID- 14757262
OWN - NLM
STAT- MEDLINE
DCOM- 20040901
LR  - 20190917
IS  - 0378-3782 (Print)
IS  - 0378-3782 (Linking)
VI  - 76
IP  - 2
DP  - 2004 Feb
TI  - Doppler-derived parameters of diastolic left ventricular function in preterm 
      infants with a birth weight <1500 g: reference values and differences to term 
      infants.
PG  - 101-14
AB  - Transmitral flow parameters in preterm and term infants were compared in order to 
      study differences in signal expression and temporal dynamics of left ventricular 
      diastolic function. In 63 preterm infants between 26 and 33 weeks of gestation 
      and 102 term infants, a Doppler survey was performed during 6 months after birth. 
      Early and atrial filling-time velocity integrals and peak velocities were 
      significantly lower in the preterm neonates. Atrial filling parameters reached 
      the level observed in term infants by 2 months of age. Peak early filling 
      velocity was still lower for 2-month-old preterms and attained the term infants' 
      level by 3 months of age. Preterm infants continued having high atrial filling 
      fraction (AFF) (0.51+/-0.07) during 2 months after birth, while in term infants 
      the fraction decreased continuously from 0.41+/-0.06 to 0.37+/-0.05. Isovolumic 
      relaxation time (IVRT) was the only parameter without differences between preterm 
      and term infants, and it decreased from 54+/-7 ms in neonates to 41+/-4 ms over 3 
      months. Stroke volume passing the mitral valve doubled in preterm (4+/-1 to 
      7.9+/-1.5 ml/cm2), but increased by only 37% (6.9+/-1.6 to 9.5+/-2.2 ml/cm2) in 
      term infants. Our observations show that the maturational period of diastolic 
      function appears prolonged in preterm infants. As preterm infants have to cope 
      with a higher physiologic preload augmentation during growth, part of the delay 
      in parameter changes might be caused by preload stress rather than by persistence 
      of functional impairment. Although doing well under physiological conditions, 
      preterm neonates may be at higher risk for diastolic dysfunction than term 
      infants when an additional preload challenge is encountered.
FAU - Schmitz, Lothar
AU  - Schmitz L
AD  - Department of Pediatric Cardiology, Charite Medical Center, Humboldt-University, 
      Augustenburger Platz 1, D-13353 Berlin, Germany. lothar.schmitz@berlin.de
FAU - Stiller, Brigitte
AU  - Stiller B
FAU - Pees, Christiane
AU  - Pees C
FAU - Koch, Heike
AU  - Koch H
FAU - Xanthopoulos, Athanasios
AU  - Xanthopoulos A
FAU - Lange, Peter
AU  - Lange P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - *Diastole
MH  - Ductus Arteriosus, Patent/diagnostic imaging/*physiopathology
MH  - Echocardiography, Doppler/*methods
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/diagnostic imaging/*physiopathology
MH  - *Infant, Very Low Birth Weight
MH  - Prospective Studies
MH  - Reference Values
MH  - Time Factors
MH  - *Ventricular Function, Left
EDAT- 2004/02/06 05:00
MHDA- 2004/09/02 05:00
CRDT- 2004/02/06 05:00
PHST- 2004/02/06 05:00 [pubmed]
PHST- 2004/09/02 05:00 [medline]
PHST- 2004/02/06 05:00 [entrez]
AID - S037837820300197X [pii]
AID - 10.1016/j.earlhumdev.2003.11.003 [doi]
PST - ppublish
SO  - Early Hum Dev. 2004 Feb;76(2):101-14. doi: 10.1016/j.earlhumdev.2003.11.003.