PMID- 14757944
OWN - NLM
STAT- MEDLINE
DCOM- 20040217
LR  - 20220316
IS  - 0278-0240 (Print)
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 19
IP  - 1
DP  - 2003-2004
TI  - Plasma homocysteine and oxidative stress in cardiovascular disease.
PG  - 27-31
AB  - Hyperhomocysteinemia (Hhcy) has been associated with pathological and stressful 
      conditions and is a risk factor for cardiovascular disease (CVD). The aim of this 
      study was to evaluate the correlation between plasma homocysteine (hcy) and lipid 
      peroxidation in patient with CVD. This study was carried out on 40 patients with 
      CVD as well as 15 healthy volunteers of comparable age and gender as control 
      group. The patients were divided into 2 groups as follows: group I, included 20 
      patients with acute myocardial infarction and group II, included 20 patients with 
      atherosclerotic coronary artery disease with no evidence of previous myocardial 
      infarction. Plasma hcy, nitric oxide (NO) and malondialdhyde (MDA) [as index of 
      lipid peroxidation] were measured in all groups. In addition serum 
      total-cholesterol, HDL, LDL and triglycerides were evaluated. Results obtained 
      showed that, there was a significant elevation in the levels of plasma hcy, NO 
      and MDA in groups I and II as compared to control group. There was a strong 
      positive correlation between plasma hcy and MDA (r = 0.59, p < 0.001). Also NO 
      was positively correlated with both hcy (r = 0.49, p < 0.001) and MDA (r = 0.51, 
      p < 0.001). Serum total cholesterol, LDL, and triglycerids were also 
      significantly elevated while serum HDL was significantly decreased in groups I 
      and II as compared to control group. It can be concluded that, 
      hyperhomocysteinemia is a possible factor in free radical generation and 
      therefore cardiovascular diseases.
FAU - Moselhy, S S
AU  - Moselhy SS
AD  - Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
FAU - Demerdash, S H
AU  - Demerdash SH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Triglycerides)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Cardiovascular Diseases/*blood
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Coronary Disease/blood
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Myocardial Infarction/blood
MH  - Nitric Oxide/blood
MH  - *Oxidative Stress
MH  - Triglycerides/blood
PMC - PMC3851381
EDAT- 2004/02/06 05:00
MHDA- 2004/02/18 05:00
PMCR- 2004/02/02
CRDT- 2004/02/06 05:00
PHST- 2004/02/06 05:00 [pubmed]
PHST- 2004/02/18 05:00 [medline]
PHST- 2004/02/06 05:00 [entrez]
PHST- 2004/02/02 00:00 [pmc-release]
AID - 10.1155/2003/137047 [doi]
PST - ppublish
SO  - Dis Markers. 2003-2004;19(1):27-31. doi: 10.1155/2003/137047.