PMID- 14758721
OWN - NLM
STAT- MEDLINE
DCOM- 20040819
LR  - 20161124
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 17
IP  - 6
DP  - 2003 Nov-Dec
TI  - Up-regulation of thymosin beta 4 gene expression in experimentally-induced 
      uterine adenomyosis in mice.
PG  - 561-5
AB  - Degradation of the myometrium contributes to the development of adenomyosis and 
      disruption of the actin cytoskeleton occurs in the myometrium adjacent to the 
      invasive endometrium. A subtractive cDNA library that contained genes 
      up-regulated in the uterus with adenomyosis induced by pituitary grafting was 
      constructed in mice. Thymosin beta 4 (Tb4), an actin sequestering protein, was 
      contained in the library and was confirmed to be abundant in the adenomyotic 
      uteri. Tb4-immunoreactivity was shown in the myometrium, with a stronger signal 
      being observed in the area closer to the tip of endometrial tissue that is 
      invading the myometrium. Up-regulation of Tb4 gene expression may be responsible 
      for the disintegration of the musculature during the development of adenomyosis.
FAU - Kawahara, Ryoka
AU  - Kawahara R
AD  - Department of Biological Sciences, Graduate School of Science, University of 
      Tokyo, Tokyo 113-0033, Japan.
FAU - Matsuda, Manabu
AU  - Matsuda M
FAU - Imaoka, Tatsuhiko
AU  - Imaoka T
FAU - Mori, Takao
AU  - Mori T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (RNA, Messenger)
RN  - 549LM7U24W (thymosin beta(4))
RN  - 61512-21-8 (Thymosin)
SB  - IM
MH  - Animals
MH  - Endometriosis/metabolism/pathology/*physiopathology
MH  - Endometrium/metabolism/pathology/*physiopathology
MH  - Female
MH  - Gene Expression
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Myometrium/metabolism/pathology/*physiopathology
MH  - RNA, Messenger/analysis
MH  - Thymosin/*genetics/metabolism
MH  - Up-Regulation
EDAT- 2004/02/05 05:00
MHDA- 2004/08/20 05:00
CRDT- 2004/02/05 05:00
PHST- 2004/02/05 05:00 [pubmed]
PHST- 2004/08/20 05:00 [medline]
PHST- 2004/02/05 05:00 [entrez]
PST - ppublish
SO  - In Vivo. 2003 Nov-Dec;17(6):561-5.