PMID- 14759216
OWN - NLM
STAT- MEDLINE
DCOM- 20040519
LR  - 20181130
IS  - 0002-7863 (Print)
IS  - 0002-7863 (Linking)
VI  - 126
IP  - 5
DP  - 2004 Feb 11
TI  - An investigation of the mechanisms of electronic sensing of protein adsorption on 
      carbon nanotube devices.
PG  - 1563-8
AB  - It has been reported that protein adsorption on single-walled carbon nanotube 
      field effect transistors (FETs) leads to appreciable changes in the electrical 
      conductance of the devices, a phenomenon that can be exploited for label-free 
      detection of biomolecules with a high potential for miniaturization. This work 
      presents an elucidation of the electronic biosensing mechanisms with a newly 
      developed microarray of nanotube "micromat" sensors. Chemical functionalization 
      schemes are devised to block selected components of the devices from protein 
      adsorption, self-assembled monolayers (SAMs) of methoxy(poly(ethylene 
      glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing 
      surfactants on the nanotubes. Extensive characterization reveals that electronic 
      effects occurring at the metal-nanotube contacts due to protein adsorption 
      constitute a more significant contribution to the electronic biosensing signal 
      than adsorption solely along the exposed lengths of the nanotubes.
FAU - Chen, Robert J
AU  - Chen RJ
AD  - Department of Chemistry, Stanford University, Stanford, California 94305, USA.
FAU - Choi, Hee Cheul
AU  - Choi HC
FAU - Bangsaruntip, Sarunya
AU  - Bangsaruntip S
FAU - Yenilmez, Erhan
AU  - Yenilmez E
FAU - Tang, Xiaowu
AU  - Tang X
FAU - Wang, Qian
AU  - Wang Q
FAU - Chang, Ying-Lan
AU  - Chang YL
FAU - Dai, Hongjie
AU  - Dai H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Proteins)
RN  - 0 (Sulfhydryl Compounds)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 5TWQ1V240M (Palladium)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Adsorption
MH  - Animals
MH  - Biosensing Techniques/*methods
MH  - Cattle
MH  - Gold/chemistry
MH  - Humans
MH  - Microscopy, Atomic Force
MH  - Nanotubes, Carbon/*chemistry
MH  - Palladium/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - Proteins/*chemistry
MH  - Sulfhydryl Compounds/chemistry
EDAT- 2004/02/05 05:00
MHDA- 2004/05/20 05:00
CRDT- 2004/02/05 05:00
PHST- 2004/02/05 05:00 [pubmed]
PHST- 2004/05/20 05:00 [medline]
PHST- 2004/02/05 05:00 [entrez]
AID - 10.1021/ja038702m [doi]
PST - ppublish
SO  - J Am Chem Soc. 2004 Feb 11;126(5):1563-8. doi: 10.1021/ja038702m.