PMID- 14760265
OWN - NLM
STAT- MEDLINE
DCOM- 20040316
LR  - 20151119
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 144
IP  - 2
DP  - 2004 Feb
TI  - Prediction of the development of tolerance to milk in children with cow's milk 
      hypersensitivity.
PG  - 218-22
AB  - OBJECTIVES: To investigate whether the development of tolerance to cow's milk 
      (CM) by aged 4 years can be predicted with a skin prick test (SPT) and 
      measurements of total or specific immunoglobulin E (IgE) in the serum, taken at 
      the time of diagnosis of cow's milk hypersensitivity (CMH). STUDY DESIGN: Infants 
      with immediate (n=95) or delayed (n=67) challenge reactions to CM were 
      prospectively followed to aged 4 years. CMH status was assessed annually by CM 
      challenges. RESULTS: By aged 2, 3, and 4 years, children with delayed reactions 
      developed tolerance to CM faster than those with immediate reactions: 64%, 92%, 
      and 96% versus 31%, 53%, and 63%, respectively. A wheal size of <5 mm in SPT 
      correctly identified 83% of 124 infants who developed tolerance to CM by aged 4 
      years, and a wheal size of >or=5 mm in SPT correctly identified 71% of 39 infants 
      with persistent CMH. Milk-specific IgE <2 kU/L correctly identified 82% of 
      infants who developed tolerance to CM, and milk-specific IgE >or=2 kU/L correctly 
      identified 71% of infants with persistent CMH. CONCLUSION: SPT and milk-specific 
      IgE in the serum are useful prognostic indicators of the development of tolerance 
      to CM in infants with CMH.
FAU - Vanto, Timo
AU  - Vanto T
AD  - Department of Pediatrics, Turku University Hospital, Turku, Finland. 
      timo.vanto@tyks.fi
FAU - Helppila, Sinikka
AU  - Helppila S
FAU - Juntunen-Backman, Kaisu
AU  - Juntunen-Backman K
FAU - Kalimo, Kirsti
AU  - Kalimo K
FAU - Klemola, Timo
AU  - Klemola T
FAU - Korpela, Riitta
AU  - Korpela R
FAU - Koskinen, Pertti
AU  - Koskinen P
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Milk Proteins)
RN  - 0 (Soybean Proteins)
RN  - 0 (Whey Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Delayed/blood/diagnosis/immunology
MH  - Hypersensitivity, Immediate/blood/diagnosis/immunology
MH  - *Immune Tolerance
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Infant Formula
MH  - Male
MH  - Milk Hypersensitivity/blood/diagnosis/*immunology
MH  - Milk Proteins/administration & dosage/*adverse effects
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Skin Tests
MH  - Soybean Proteins/administration & dosage
MH  - Whey Proteins
EDAT- 2004/02/05 05:00
MHDA- 2004/03/18 05:00
CRDT- 2004/02/05 05:00
PHST- 2004/02/05 05:00 [pubmed]
PHST- 2004/03/18 05:00 [medline]
PHST- 2004/02/05 05:00 [entrez]
AID - S0022-3476(03)00809-6 [pii]
AID - 10.1016/j.jpeds.2003.10.063 [doi]
PST - ppublish
SO  - J Pediatr. 2004 Feb;144(2):218-22. doi: 10.1016/j.jpeds.2003.10.063.