PMID- 14761689
OWN - NLM
STAT- MEDLINE
DCOM- 20040409
LR  - 20131121
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 55
IP  - 2
DP  - 2004 Apr
TI  - Effects of chronic exposure of 2,4-dichlorophenol on the antioxidant system in 
      liver of freshwater fish Carassius auratus.
PG  - 167-74
AB  - There were few reports on the antioxidant response of aquatic organisms exposed 
      to 2,4-dichlorophenol (2,4-DCP). This research explored the hepatic antioxidant 
      responses of fish to long-term exposure of 2,4-DCP for the first time. Freshwater 
      fish Carassius auratus were chosen as experimental animals. The fish were exposed 
      to six different concentrations of 2,4-DCP (0.005-1.0 mg/l) for 40 days and then 
      liver tissues were separated for determination. As shown from the results, 40 
      days afterwards, the activities of catalase (CAT) and selenium-dependent 
      glutathione peroxidase (Se-GPx) and the content of oxidized glutathione (GSSG) 
      were induced significantly on the whole compared to control group; superoxide 
      dismutase (SOD) responded to 2,4-DCP exposure at only 0.005 mg/l; the content of 
      reduced glutathione (GSH) was suppressed continuously except Group 7; the 
      activity of glutathione reductase was inhibited initially and then restored to 
      control level from Group 4 on; glutathione S-transferase had only slight 
      responses in Groups 3 and 4. Total glutathione (tGSH) and GSH/GSSG ratio were 
      also calculated to analyze the occurrence of oxidative stress. Besides, good 
      dose-effect relations, which cover most of the exposure concentration range, were 
      found between 2,4-DCP level and CAT activity, GSSG content, Se-GPx activity, 
      respectively. In conclusion, SOD and Se-GPx may be potential early biomarkers of 
      2,4-DCP contamination in aquatic ecosystems, and further studies will be 
      necessary.
FAU - Zhang, Jingfei
AU  - Zhang J
AD  - State Key Laboratory of Pollution Control and Resources Reuse, School of 
      Environment, Nanjing University, Nanjing 210093, People's Republic of China.
FAU - Shen, Hua
AU  - Shen H
FAU - Wang, Xiaorong
AU  - Wang X
FAU - Wu, Jichun
AU  - Wu J
FAU - Xue, Yuqun
AU  - Xue Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Chlorophenols)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Catalase/metabolism
MH  - China
MH  - Chlorophenols/*toxicity
MH  - Fresh Water
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Goldfish/*metabolism
MH  - Liver/*drug effects/metabolism
MH  - Superoxide Dismutase/metabolism
EDAT- 2004/02/06 05:00
MHDA- 2004/04/10 05:00
CRDT- 2004/02/06 05:00
PHST- 2003/03/03 00:00 [received]
PHST- 2003/09/30 00:00 [revised]
PHST- 2003/10/24 00:00 [accepted]
PHST- 2004/02/06 05:00 [pubmed]
PHST- 2004/04/10 05:00 [medline]
PHST- 2004/02/06 05:00 [entrez]
AID - S0045-6535(03)01062-2 [pii]
AID - 10.1016/j.chemosphere.2003.10.048 [doi]
PST - ppublish
SO  - Chemosphere. 2004 Apr;55(2):167-74. doi: 10.1016/j.chemosphere.2003.10.048.