PMID- 14763917
OWN - NLM
STAT- MEDLINE
DCOM- 20040330
LR  - 20221207
IS  - 0804-4643 (Print)
IS  - 0804-4643 (Linking)
VI  - 150
IP  - 2
DP  - 2004 Feb
TI  - Body weight and glucose metabolism have a different effect on circulating levels 
      of ICAM-1, E-selectin, and endothelin-1 in humans.
PG  - 195-200
AB  - BACKGROUND: Endothelial dysfunction and inflammation are present in both type 2 
      diabetes mellitus (T2DM) and obesity. In this paper we compared the role of 
      weight loss and of glycaemic control in determining circulating levels of ICAM-1, 
      endothelin-1 (ET-1), and E-selectin in patients with morbid (grade 3) obesity. 
      METHODS AND RESULTS: ICAM-1, E-selectin, and ET-1 were higher in obese patients 
      (n=96) than in lean controls (n=30); among obese patients, the three molecules 
      were higher in T2DM patients (n=26) than in patients with normal (NGT, n=43) or 
      impaired (IGT, n=27) glucose tolerance. Sixty-eight obese patients had a 
      significant weight loss induced by bariatric surgery, and showed a significant 
      decrease in blood glucose, HbA1c and all molecules, so that ICAM-1, E-selectin, 
      and ET-1 were not different in NGT, IGT and T2DM patients, and in lean controls; 
      in 13 patients with a small weight loss induced by diet, changes were not 
      significant, in spite of a significant reduction in blood glucose and HbA1c. At 
      stepwise regression, changes in ICAM-1, ET-1, and E-selectin significantly 
      correlated only with change in body mass index. CONCLUSIONS: These data indicate 
      that weight loss is more important than glycaemic control in regulating 
      circulating levels of ICAM-1, ET-1, E-selectin in morbidly obese subjects.
FAU - Pontiroli, Antonio E
AU  - Pontiroli AE
AD  - Cattedra di Medicina Interna, Universita degli Studi, 2nd Divisione di Medicina 
      Interna, Ospedale San Paolo, Italy. antonio.pontiroli@unimi.it
FAU - Pizzocri, Pierluigi
AU  - Pizzocri P
FAU - Koprivec, Diana
AU  - Koprivec D
FAU - Vedani, Paola
AU  - Vedani P
FAU - Marchi, Monica
AU  - Marchi M
FAU - Arcelloni, Cinzia
AU  - Arcelloni C
FAU - Paroni, Rita
AU  - Paroni R
FAU - Esposito, Katherine
AU  - Esposito K
FAU - Giugliano, Dario
AU  - Giugliano D
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Blood Glucose)
RN  - 0 (E-Selectin)
RN  - 0 (Endothelin-1)
RN  - 0 (Glycated Hemoglobin A)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Weight/physiology
MH  - Diabetes Mellitus, Type 2/blood/complications
MH  - E-Selectin/*blood
MH  - Endothelin-1/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/blood
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Male
MH  - Matched-Pair Analysis
MH  - Middle Aged
MH  - Obesity, Morbid/complications/*metabolism
MH  - Reference Values
MH  - Regression Analysis
MH  - Weight Loss/physiology
EDAT- 2004/02/07 05:00
MHDA- 2004/03/31 05:00
CRDT- 2004/02/07 05:00
PHST- 2004/02/07 05:00 [pubmed]
PHST- 2004/03/31 05:00 [medline]
PHST- 2004/02/07 05:00 [entrez]
AID - 1500195 [pii]
AID - 10.1530/eje.0.1500195 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2004 Feb;150(2):195-200. doi: 10.1530/eje.0.1500195.