PMID- 14763929
OWN - NLM
STAT- MEDLINE
DCOM- 20040525
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 2
DP  - 2004 Feb
TI  - Association between the occurrence of the anticardiolipin IgM and mite 
      allergen-specific IgE antibodies in children with extrinsic type of atopic 
      eczema/dermatitis syndrome.
PG  - 164-7
AB  - BACKGROUND: As the literature has only controversial data on the role of 
      nonallergen-specific antibodies in atopic eczema dermatitis syndrome, the authors 
      investigated the link between the occurrence of the antiphospholipid 
      [anticardiolipin (ACL), anti-beta2-glycoprotein I] and allergen-specific 
      immunoglobulin E (IgE) antibodies in 72 children with atopic eczema/dermatitis 
      syndrome (AEDS). METHODS: The measurement of antiphospholipid antibodies was 
      carried out by enzyme-linked immunosorbent assay (ELISA), serum total IgE by 
      nephelometry, and allergen-specific IgE by immunoblotting assay. The statistical 
      analysis was carried out by Fisher's exact test and odds ratio was calculated. 
      RESULTS: Thirteen of 72 children with AEDS (mean age 8.3 years) had elevated 
      serum levels of ACL, and eight anti-beta2-glycoprotein I antibodies. The presence 
      of allergen-specific IgE against inhalant allergens and nutritive allergens was 
      among eight of 13 and three of eight in the cases with elevated ACL. The ratio of 
      patients with highly increased severity scoring of atopic dermatitis (SCORAD) 
      index (>75) was significantly higher in the group with elevated (4/13) than in 
      those with the normal ACL levels (2/59). There was a significant association 
      between the appearance of mite (Dermatophagoides pteronyssinus, D. 
      farinae)-specific IgE and ACL IgM antibodies (6/13). CONCLUSION: These findings 
      show that there are significant linkage and association between the appearance of 
      ACL IgM or the production of allergen-specific IgE against inhalant (mainly mite) 
      allergens in children with atopic eczema/dermatitis syndrome.
FAU - Szakos, E
AU  - Szakos E
AD  - Borsod-A-Z County and University Teaching Hospital, Pediatric Health Centre, 
      Miskolc, Hungary.
FAU - Lakos, G
AU  - Lakos G
FAU - Aleksza, M
AU  - Aleksza M
FAU - Gyimesi, E
AU  - Gyimesi E
FAU - Pall, G
AU  - Pall G
FAU - Fodor, B
AU  - Fodor B
FAU - Hunyadi, J
AU  - Hunyadi J
FAU - Solyom, E
AU  - Solyom E
FAU - Sipka, S
AU  - Sipka S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Autoantibodies)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin M)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Allergy. 2004 Feb;59(2):162-3. PMID: 14763928
MH  - Adolescent
MH  - Allergens/immunology
MH  - Antibodies/*blood
MH  - Antibodies, Anticardiolipin/*blood
MH  - *Antibody Specificity
MH  - Antigens, Dermatophagoides/*immunology
MH  - Autoantibodies/blood
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycoproteins/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin M/*blood
MH  - Male
MH  - beta 2-Glycoprotein I
EDAT- 2004/02/07 05:00
MHDA- 2004/05/27 05:00
CRDT- 2004/02/07 05:00
PHST- 2004/02/07 05:00 [pubmed]
PHST- 2004/05/27 05:00 [medline]
PHST- 2004/02/07 05:00 [entrez]
AID - 367 [pii]
AID - 10.1046/j.1398-9995.2003.00367.x [doi]
PST - ppublish
SO  - Allergy. 2004 Feb;59(2):164-7. doi: 10.1046/j.1398-9995.2003.00367.x.