PMID- 14764661
OWN - NLM
STAT- MEDLINE
DCOM- 20040615
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 172
IP  - 4
DP  - 2004 Feb 15
TI  - Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in 
      priming CTL immunity to viruses.
PG  - 1996-2000
AB  - Dendritic cells (DCs) play a central role in initiating immune responses. Despite 
      this, there is little understanding how different DC subsets contribute to 
      immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity 
      to HSV. Whether this very limited capacity of a single DC subset priming CTL 
      immunity is restricted to HSV infection or is a more general property of 
      anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the 
      principal DC subset that initiates CTL immunity to s.c. infection by influenza 
      virus, HSV, and vaccinia virus. This same subset also dominated immunity after 
      i.v. infection with all three viruses, suggesting a similar involvement in other 
      routes of infection. These data highlight the general role played by CD8alpha(+) 
      DCs in CTL priming to viral infection and raises the possibility that this DC 
      subset is specialized for viral immunity.
FAU - Belz, Gabrielle T
AU  - Belz GT
AD  - Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 
      Melbourne, Australia.
FAU - Smith, Christopher M
AU  - Smith CM
FAU - Eichner, Daniel
AU  - Eichner D
FAU - Shortman, Ken
AU  - Shortman K
FAU - Karupiah, Guna
AU  - Karupiah G
FAU - Carbone, Francis R
AU  - Carbone FR
FAU - Heath, William R
AU  - Heath WR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (CD8 Antigens)
RN  - 0 (CD8alpha antigen)
SB  - IM
MH  - Animals
MH  - CD8 Antigens/*biosynthesis
MH  - Cell Division/immunology
MH  - Cell Separation
MH  - Dendritic Cells/*immunology/metabolism/*virology
MH  - Herpes Simplex/*immunology
MH  - Immunity, Cellular
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Interphase/immunology
MH  - Lymph Nodes/cytology/immunology/virology
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Orthomyxoviridae Infections/*immunology
MH  - Spleen/cytology/immunology/virology
MH  - T-Lymphocytes, Cytotoxic/*immunology/*virology
MH  - Vaccinia/*immunology
EDAT- 2004/02/07 05:00
MHDA- 2004/06/16 05:00
CRDT- 2004/02/07 05:00
PHST- 2004/02/07 05:00 [pubmed]
PHST- 2004/06/16 05:00 [medline]
PHST- 2004/02/07 05:00 [entrez]
AID - 10.4049/jimmunol.172.4.1996 [doi]
PST - ppublish
SO  - J Immunol. 2004 Feb 15;172(4):1996-2000. doi: 10.4049/jimmunol.172.4.1996.