PMID- 14768774
OWN - NLM
STAT- MEDLINE
DCOM- 20040514
LR  - 20220311
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 16
IP  - 4
DP  - 2003 Aug
TI  - The interrelationship between insulin secretion and action in type 2 diabetes 
      mellitus with different degrees of obesity: evidence supporting central obesity.
PG  - 243-50
AB  - This paper investigates the relative role of the impairment of insulin secretion 
      and action in the pathogenesis of Type 2 diabetes mellitus (T2DM). The parameters 
      indicating insulin secretion and action were calculated from the data obtained 
      during oral glucose tolerance test (OGTT), in 156 age- and sex-matched T2DM 
      patients divided in 4 groups according to their body mass index (BMI, I = 
      20.0-24.9, II = 25.0-29.9, III = 30.0-39.9 and IV > 40.0 kg/m2). After obtaining 
      baseline biomedical parameters (plasma glucose, serum insulin, cholesterol, 
      HDL-cholesterol, triglycerides, BMI, and amount of fat tissue), the rates of 
      insulin secretory capacity and insulin action were obtained from OGTT and 
      compared between the T2DM patients with normal body weight and different grades 
      of obesity. Beta-cell secretory capacity of the participants was found to be 
      proportionally and significantly higher in graded obese than that of the normal 
      body weight patients. The rates of hepatic as well as peripheral insulin 
      resistance in obese groups proportionally and significantly rise in comparison 
      with that of non-obese diabetics. In addition, these parameters are shown to be 
      related to the body fat, presumably visceral in origin. In conclusion, 
      hyperglycemia-hyperinsulinemia observed in obese and T2DM patients might be due, 
      in part, to increased capacity of insulin secretion, and to exaggerated hepatic 
      glucose production because of hepatic insulin resistance, respectively.
FAU - Duman, B Susleyici
AU  - Duman BS
AD  - Department of Medical Biology and Genetics, Kadir Has University, School of 
      Medicine, Vefa Bey Sok. No. 5, 80810-Gayrettepe-Istanbul, Turkey. 
      bsusleyici@khas.edu.tr
FAU - Turkoglu, C
AU  - Turkoglu C
FAU - Gunay, D
AU  - Gunay D
FAU - Cagatay, P
AU  - Cagatay P
FAU - Demiroglu, C
AU  - Demiroglu C
FAU - Buyukdevrim, A Sevim
AU  - Buyukdevrim AS
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Abdomen
MH  - Adipose Tissue
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Composition
MH  - Body Constitution
MH  - Body Mass Index
MH  - Body Weight
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Diabetes Mellitus/*physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Glucose/biosynthesis
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood/*metabolism/*pharmacology
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Islets of Langerhans/metabolism
MH  - Liver/drug effects/metabolism
MH  - Middle Aged
MH  - *Obesity
MH  - Triglycerides/blood
EDAT- 2004/02/11 05:00
MHDA- 2004/05/15 05:00
CRDT- 2004/02/11 05:00
PHST- 2004/02/11 05:00 [pubmed]
PHST- 2004/05/15 05:00 [medline]
PHST- 2004/02/11 05:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2003 Aug;16(4):243-50.