PMID- 14769358
OWN - NLM
STAT- MEDLINE
DCOM- 20040402
LR  - 20151119
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 184
IP  - 2
DP  - 2003 Dec
TI  - Identification and expression of the gene for human ataxin-2-related protein on 
      chromosome 16.
PG  - 669-78
AB  - Spinocerebellar ataxia type 2 (SCA2) is a human neurodegenerative disease caused 
      by mutation in the ataxin-2 gene on human chromosome 12. Ataxin-2 is a protein of 
      unknown function. We identified a new family of proteins designated as 
      ataxin-2-related proteins (A2RPs), with high homology at the nucleotide and 
      predicted amino acid levels. Ataxin-2 and A2RP are proteins highly conserved in 
      evolution with orthologs in mouse, cattle, pig, frog, and plants. A2RP has 
      several isoforms with different C-terminal domains. The longest isoform is 
      composed of 1051 amino acids and has widespread expression in human tissues by 
      Northern and Western blot analyses.
FAU - Figueroa, Karla P
AU  - Figueroa KP
AD  - Rose Moss Neurogenetics Laboratory for Parkinson and Related Diseases, CSMS Burns 
      and Allen Research Institute, Division of Neurology, Cedars-Sinai Medical Center, 
      8700 Beverly Boulevard, Los Angeles, CA 90048, USA. PULST@CSHS.ORG
FAU - Pulst, Stefan M
AU  - Pulst SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Ataxins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Ataxins
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 16
MH  - Cloning, Molecular
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins
MH  - Protein Isoforms/chemistry/genetics
MH  - Proteins/*chemistry/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Analysis, Protein
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Species Specificity
MH  - Spinocerebellar Ataxias/genetics
EDAT- 2004/02/11 05:00
MHDA- 2004/04/03 05:00
CRDT- 2004/02/11 05:00
PHST- 2003/01/06 00:00 [received]
PHST- 2003/05/15 00:00 [revised]
PHST- 2003/05/21 00:00 [accepted]
PHST- 2004/02/11 05:00 [pubmed]
PHST- 2004/04/03 05:00 [medline]
PHST- 2004/02/11 05:00 [entrez]
AID - S0014488603002875 [pii]
AID - 10.1016/S0014-4886(03)00287-5 [doi]
PST - ppublish
SO  - Exp Neurol. 2003 Dec;184(2):669-78. doi: 10.1016/S0014-4886(03)00287-5.