PMID- 14769378
OWN - NLM
STAT- MEDLINE
DCOM- 20040402
LR  - 20081121
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 184
IP  - 2
DP  - 2003 Dec
TI  - Transforming growth factor beta 1 may regulate the stability of mature myelin 
      sheaths.
PG  - 857-64
AB  - The molecular mechanisms underlying peripheral neuropathies have only been 
      partially elucidated. In particular, the regulatory factors that control the 
      stability and turnover of mature myelin are largely unknown. Transforming growth 
      factor beta 1 (TGF-beta1), and its associated receptors, are expressed by mature 
      Schwann cells. On this basis, we postulated that TGF-beta1 may be an autocrine 
      regulator of mature myelin. This hypothesis was tested by examining the 
      ultrastructure of myelin in adult mice that have a null mutation of their 
      TGF-beta1 gene. We report here that the myelin of these mice is grossly abnormal. 
      At the nodes of Ranvier, the cytoplasmic collars of the Schwann cells were 
      expanded and the myelin had a honeycomb appearance. Focal (tomacula-like) 
      hypermyelin structures were observed in the internodal regions of a significant 
      number of axons in mutant nerve, and were not observed in littermate controls. 
      Axon diameters were within the normal range and no axonal pathology was evident 
      in mutant nerve and macrophages were absent. Results imply that lack of TGF-beta1 
      may have a direct effect on Schwann cells. We suggest that TGF-beta1 may 
      stabilise compact myelin via an autocrine mechanism.
FAU - Day, W Antony
AU  - Day WA
AD  - Arizona Research Laboratories, Department of Neuroscience, University of Arizona, 
      Tucson, AZ, USA.
FAU - Koishi, Kyoko
AU  - Koishi K
FAU - McLennan, Ian S
AU  - McLennan IS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Tgfb1 protein, mouse)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Animals
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Hairless
MH  - Mice, Knockout
MH  - Microscopy, Electron
MH  - Mutation
MH  - Myelin Sheath/*pathology/ultrastructure
MH  - Ranvier's Nodes/pathology/ultrastructure
MH  - Sciatic Nerve/*pathology/ultrastructure
MH  - Transforming Growth Factor beta/*genetics
MH  - Transforming Growth Factor beta1
EDAT- 2004/02/11 05:00
MHDA- 2004/04/03 05:00
CRDT- 2004/02/11 05:00
PHST- 2002/08/13 00:00 [received]
PHST- 2003/06/09 00:00 [revised]
PHST- 2003/06/10 00:00 [accepted]
PHST- 2004/02/11 05:00 [pubmed]
PHST- 2004/04/03 05:00 [medline]
PHST- 2004/02/11 05:00 [entrez]
AID - S001448860300308X [pii]
AID - 10.1016/S0014-4886(03)00308-X [doi]
PST - ppublish
SO  - Exp Neurol. 2003 Dec;184(2):857-64. doi: 10.1016/S0014-4886(03)00308-X.